Human VCAM-1/CD106 ELISA Kit (Colorimetric)
货号：
NBP1-91177 基本售价：
8308.3 元 规格：
96 Tests
产品信息
概述| 货号 | NBP1-91177 |
| 反应种属 | HuSpecies Glossary |
| 应用 | ELISA |
性能| 供应商 | Novus |
| 背景 | The vascular cell adhesion molecule-1 (VCAM-1) or CD106 is a member of the immunoglobulin gene superfamily. The initial molecular cloning of VCAM-1 reported six extracellular Ig-like domains (6D VCAM-1). This 6D VCAM-1 arises due to alternative splicing from a seven-domain VCAM-1 (7D VCAM-1). 7D VCAM-1 is the dominant form expressed by cultured human endothelial cells. Domains 1 through 3 are highly homologous to domains 4 through 6, suggesting that they arose by gene duplication. VCAM-1 is not constitutively expressed on endothelium, but can be upregulated in vitro in response to LPS, TNF-a, and IL-1, as well as to IFN-gamma and IL-4. VCAM-1 is also present on tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts and myotubes. A soluble form of VCAM-1 (sVCAM-1) has been described. Soluble VCAM-1 levels have been found in the serum of healthy individuals and increased levels of sVCAM-1 can be detected in several diseases. Cancer: ovarian, gastric-intestinal, renal, bladder cancer, non-Hodgkins lymphoma, breast cancer (cyst fluid). Autoimmune diseases: multiple sclerosis (cerebrospinal fluid), systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis. Infections: sepsis, meningitis, malaria. Inflammation: vasculitis, alcoholic cirrhosis, primary biliary cirrhosis, Wegeners granulomatosis. |
| 存放说明 | Storage of components varies. See protocol for specific instructions. |
