Human TNF RII/TNFRSF1B ELISA Kit (Colorimetric)
货号：
NBP1-88105 基本售价：
8308.3 元 规格：
96 Tests
产品信息
概述| 货号 | NBP1-88105 |
| 反应种属 | HuSpecies Glossary |
| 应用 | ELISA |
性能| 供应商 | Novus |
| 背景 | Tumor Necrosis Factor (TNF) was originally discovered in sera of animals and was found to cause hemorrhagic necrosis of some transplantable mouse and human tumors and to exhibit primarily cytotoxic activities against tumor but not normal cells in vitro. The TNF family consists of two proteins designated TNF-alpha, also called cachectin, and TNF-beta, also called lymphotoxin, which are pleiotropic cytokines that can mediate a wide variety of biological effects. Both TNF-alpha and TNF-beta have been shown to interact with a cell through specific high affinity receptors with a few hundred up to more than 20,000 copies per cell. TNF-receptors have been demonstrated on a wide variety of human somatic cells including fibroblasts, endothelial cells, adipocytes, liver membranes, granulocytes and several tumor cell lines. The predicted amino acid sequences of the extracellular regions of the two TNF-R reveal significant similarities. They share 28 % identity on their extracellular domain, but their intracellular parts are totally different from each other. The present assay provides a simple, rapid and highly sensitive method for the determination of soluble TNF-R (80 kDa) levels in body fluids or cell culture supernatants. This assay will help to clarify the possible diagnostic and prognostic value of circulating sTNF-R (80 kDa) in various neoplastic and inflammatory diseases. |
| 存放说明 | Storage of components varies. See protocol for specific instructions. |
