Human VEGF R2/KDR/Flk-1 ELISA Kit (Colorimetric)
货号：
NBP1-83729 基本售价：
8308.3 元 规格：
96 Tests
产品信息
概述| 货号 | NBP1-83729 |
| 反应种属 | HuSpecies Glossary |
| 应用 | ELISA |
性能| 供应商 | Novus |
| 背景 | VEGF-A (also called VEGF) and its receptors represent the best characterized signalling pathway in developmental and tumour angiogenesis. VEGF-A binds to two receptor-tyrosine kinases: VEGFR-1/Flt-1 and VEGFR-2/KDR. VEGFR-2 is the major mediator of the mitogenic, angiogenic and permeability-enhancing effects of VEGF-A. The VEGFRs possess an approximately 750 amino acid residue extracellular domain, which is organized into seven immunoglobulin (Ig)- like folds. This extracellular domain is followed by a single transmembrane region, a juxtamembrane domain, a split tyrosine-kinase domain interrupted by a 70-amino acid kinase insert and a C-terminal tail. Alternative splicing or proteolytic processing of VEGFRs gives rise to secreted variants of VEGFR-2, also called soluble VEGFR-2. Although the VEGFRs are primarily expressed in the vascular system, sensitive methods like sandwich ELISAs have allowed the detection of VEGFR expression in non-endothelial cells like hematopoietic stem cells. Besides its putative role as a surrogate marker for tumour angiogenesis, naturally occurring sVEGFR-2 is a molecular regulator for VEGF and VEGFR signalling. |
| 存放说明 | Storage of components varies. See protocol for specific instructions. |
