Mouse IL-23 R ELISA Kit (Colorimetric)
货号：
NBP1-92664 基本售价：
7812.6 元 规格：
96 Tests
产品信息
概述| 货号 | NBP1-92664 |
| 反应种属 | MuSpecies Glossary |
| 应用 | ELISA |
性能| 供应商 | Novus |
| 背景 | Interleukin-23 was found during a genome scan for the IL-6/IL-12 cytokine family. IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit, which is IL-23 specific. IL-23 uses many of the same signal-transduction components as IL-12, so it binds to IL-12Rbeta1 receptor, but not IL-12Rbeta2. IL-23 plays a role in type 1-polarized T-cell immune responses. Although IL-12 strongly activates naive T-cells, the initial description of IL-23 reported preferential actions on memory T-cells to increase IFN-gamma production and proliferation suggesting an important role for IL-23 in controlling bacterial infections. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. IL-23 was shown to be involved in inflammation of the nervous system and autoimmune diseases. |
| 存放说明 | Storage of components varies. See protocol for specific instructions. |
