| 货号 | DVDBP0B |
| 描述 | The Quantikine Human Vitamin D Binding Protein immunoassay is a 3.5 hour solid phase ELISA designed to measure Vitamin D Binding Protein in cell culture supernates, serum, plasma, saliva, urine, and human milk. It contains natural human Vitamin D Binding Protein Standard. This kit can be used to determine mass values for naturally occurring human Vitamin D Binding Protein. |
| 别名 | DBP; DBP/GC; DBP-MAF; DBPVDBG; EC 6.3.1.5; Gc; gc-globulin; Gc-MAF; GRD3; group-specific component (vitamin D binding protein); Group-specific component; hDBP; VDB; VDBG; VDBP; Vitamin D BP; vitamin D-binding alpha-globulin; vitamin D-binding protein; | 全称 | Vitamin D Binding Protein |
| 目标/特异性 | Natural human Vitamin D Binding Protein |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2638 (Human); 14473 (Mouse); 24384 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women | |
| 生物活性 | < 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested. |
| 背景 | Vitamin D binding protein (VitD BP), also known as DBP and Gc-globulin, is a 58 kDa glycoprotein that circulates at high concentration in the serum and serves as a carrier protein for vitamin D. The transport of vitamin D by VitD BP is important for the function of a wide variety of tissues. VitD BP binds both the 25(OH) and the hormonally active 1,25(OH)2 forms of vitamin D. VitD BP is primarily expressed in hepatocytes and to a lesser extent in the kidney. It delivers vitamin D into cells by Megalin-mediated endocytosis. A selectively deglycosylated form of VitD BP known as macrophage activating factor (MAF) blocks the angiogenic effects of FGF basic, VEGF, and Angiopoietin 2. VitD BP enhances the chemotaxis of monocytes and neutrophils to the activated complement component C5a or C5a des Arg (a C-terminally processed form of C5a). The chemotactic cofactor property of VitD BP is eliminated by binding to 1,25(OH)2 vitamin D, but it is not altered by binding to 25(OH) vitamin D or actin. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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