| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates
Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis.
Respir. Res., 2012;13(0):34.
Species: Human
Sample Type: Serum
Co-expression of alpha9beta1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.
Authors: Majumder M, Tutunea-Fatan E, Xin X, Rodriguez-Torres M, Torres-Garcia J, Wiebe R, Timoshenko AV, Bhattacharjee RN, Chambers AF, Lala PK
PLoS ONE, 2012;7(4):e35094.
Species: Human
Sample Type: Cell Culture Supernates
Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2589-95.
Species: Human
Sample Type: Serum
Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease.
Authors: Dabora SL, Franz DN, Ashwal S, Sagalowsky A, DiMario FJ, Miles D, Cutler D, Krueger D, Uppot RN, Rabenou R, Camposano S, Paolini J, Fennessy F, Lee N, Woodrum C, Manola J, Garber J, Thiele EA
PLoS ONE, 2011;6(9):e23379.
Species: Human
Sample Type: Serum
Autocrine effects of VEGF-D on endothelial cells after transduction with AD-VEGF-D(DeltaNDeltaC).
Authors: Papiewska-Pajak I, Boncela J, Przygodzka P, Cierniewski CS
Exp. Cell Res., 2010;316(6):907-14.
Species: Human
Sample Type: Cell Culture Supernates
Phase I and pharmacological study of the broad-spectrum tyrosine kinase inhibitor JNJ-26483327 in patients with advanced solid tumours.
Authors: Konings IR, de Jonge MJ, Burger H
Br. J. Cancer, 2010;103(7):987-92.
Species: Human
Sample Type: Serum
Impaired lymphangiogenesis due to excess vascular endothelial growth factor-D/Flt-4 signalling in the skin of patients with systemic sclerosis.
Authors: Honda N, Jinnin M, Kajihara I, Makino T, Fukushima S, Ihn H
Br. J. Dermatol., 2010;163(4):776-80.
Species: Human
Sample Type: Serum
Novel vascular endothelial growth factor D variants with increased biological activity.
Authors: Toivanen PI, Nieminen T, Viitanen L, Alitalo A, Roschier M, Jauhiainen S, Markkanen JE, Laitinen OH, Airenne TT, Salminen TA, Johnson MS, Airenne KJ, Yla-Herttuala S
J. Biol. Chem., 2009;284(23):16037-48.
Species: Human
Sample Type: Cell Culture Supernates
Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement.
Authors: Glasgow CG, Avila NA, Lin JP, Stylianou MP, Moss J
Chest, 2009;135(5):1293-300.
Species: Human
Sample Type: Serum
Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines.
Authors: Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI, Kirkpatrick CJ
Int. J. Oncol., 2008;32(3):585-92.
Species: Human
Sample Type: Cell Culture Supernates
Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates
Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia.
Authors: Lee CY, Tien HF, Hu CY, Chou WC, Lin LI
Br. J. Cancer, 2007;97(7):877-82.
Species: Human
Sample Type: Plasma
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle.
Authors: Kholova I, Koota S, Kaskenpaa N, Leppanen P, Narvainen J, Kavec M, Rissanen TT, Hazes T, Korpisalo P, Grohn O, Yla-Herttuala S
Hum. Gene Ther., 2007;18(3):232-44.
Species: Human
Sample Type: Plasma
Umbilical Cord Blood-derived Progenitor Cells Enhance Muscle Regeneration in Mouse Hindlimb Ischemia Model.
Authors: Koponen JK, Kekarainen T, E Heinonen S, Laitinen A, Nystedt J, Laine J, Yla-Herttuala S
Mol. Ther., 2007;15(12):2172-7.
Species: Human
Sample Type: Cell Culture Supernates
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
Authors: Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte L, Alitalo K
Cancer Res., 2007;67(2):593-9.
Species: Human
Sample Type: Cell Culture Supernates
Changes in the circulating plasma levels of VEGF and VEGF-D after adjuvant chemotherapy in patients with breast cancer and 1 to 3 positive lymph nodes.
Authors: Kummel S, Eggemann H, Luftner D, Thomas A, Jeschke S, Zerfel N, Heilmann V, Emons G, Zeiser T, Ulm K, Kobl M, Korlach S, Schmid P, Sehouli J, Elling D, Blohmer JU
Anticancer Res., 2006;26(2):1719-26.
Species: Human
Sample Type: Plasma
A potential role for vascular endothelial growth factor-D as an autocrine growth factor for human breast carcinoma cells.
Authors: Akahane M, Akahane T, Shah A, Okajima E, Thorgeirsson UP
Anticancer Res., 2005;25(2):701-7.
Species: Human
Sample Type: Cell Culture Supernates
Serum level of VEGF-D in patients with primary lymphedema.
Authors: Fink AM, Kaltenegger I, Schneider B, Fruhauf J, Jurecka W
Lymphology, 2004;37(4):185-9.
Species: Human
Sample Type: Serum
VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression.
Authors: George ML, Tutton MG, Janssen F, Arnaout A, Abulafi AM, Eccles SA, Swift RI
Neoplasia, 2001;3(5):420-7.
Species: Human
Sample Type: Serum
|
| 背景 | Vascular endothelia growth factor D (VEGF-D), also known as c-fos-induced growth factor (FIGF), is a secreted glycoprotein of the VEGF/PDGF family. VEGFs regulate angiogenesis and lymphangiogenesis during development and tumor growth, and are characterized by eight conserved cysteine residues that form a cystine knot structure. VEGF-C and VEGF-D, which share 23% amino acid (aa) sequence identity, are uniquely expressed as preproproteins that contain long N- and C-terminal propeptide extensions around the VEGF homology domain (VHD). Proteolytic processing of the 354 aa VEGF-D preproprotein creates a secreted proprotein. Further processing by extracellular serine proteases, such as plasmin or furin-like proprotein convertases, forms mature VEGF-D consisting of non-covalently linked 42 kDa homodimers of the 117 aa VHD. Mature human VEGF-D shares 94%, 95%, 99%, 97% and 93% aa identity with mouse, rat, equine, canine and bovine VEGF-D, respectively. It is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs and skin. Mouse and human VEGF-D are ligands for VEGF receptor 3 (VEGF R3, also called Flt-4) that are active across species and show enhanced affinity when processed. Processed human VEGF-D is also a ligand for VEGF R2, also called Flk-1 or KDR. VEGF R3 is strongly expressed in lymphatic endothelial cells and is essential for regulation of the growth and differentiation of lymphatic endothelium. While VEGF-C is the critical ligand for VEGF R3 during embryonic lymphatic development, VEGF-D is most active in neonatal lymphatic maturation and bone growth. Both promote tumor lymphangiogenesis. Consonant with their activity on VEGF receptors, binding of VEGF-C and VEGF-D to neuropilins contributes to VEGF R3 signaling in lymphangiogenesis, while binding to integrin α9β1 mediates endothelial cell adhesion and migration. |
