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Human VEGF-C Quantikine ELISA Kit (1 KT)

货号: DVEC00 基本售价: 7356.5 元 规格: 1 Kit

产品信息

概述
货号DVEC00
描述The Quantikine Human VEGF-C Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human VEGF-C in cell culture supernates, serum, plasma, and saliva. It contains NS0-expressed recombinant human VEGF-C (Cys156Ser substituted) and has been shown to accurately quantitate the recombinant factor. Results obtained using recombinant human VEGF-C (wild type) and natural human VEGF-C showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human VEGF-C.
别名Flt4 ligand; Flt4-L; vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGF-C; VRPFLT4 ligand DHM;
全称
Vascular Endothelial Growth Factor C
反应种属Human
目标/特异性Natural human VEGF-C, recombinant human VEGF-C (wild type), and recombinant human VEGF-C (Cys156Ser substituted)
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
7424 (Human); 22341 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates

Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer.
Authors: Tokumoto M, Tanaka H, Tauchi Y, Kasashima H, Kurata K, Yashiro M, Sakurai K, Toyokawa T, Kubo N, Amano R, Kimura K, Muguruma K, Maeda K, Ohira M, Hirakawa K
Br J Cancer, 2015;113(7):1046-54.
Species: Human
Sample Type: Cell Culture Supernates

KML001 inhibits cell proliferation and invasion in pancreatic cancer cells through suppression of NF-kappaB and VEGF-C.
Authors: Yang M, Kim H, Lee K, Yang S, Lee J, Lee K, Rhee J
Anticancer Res, 2014;34(7):3469-74.
Species: Human
Sample Type: Cell culture supernatant

Telmisartan, a possible PPAR-delta agonist, reduces TNF-alpha-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells.
Authors: Kimura H, Mikami D, Kamiyama K, Sugimoto H, Kasuno K, Takahashi N, Yoshida H, Iwano M
Biochem Biophys Res Commun, 2014;454(2):320-7.
Species: Human
Sample Type: cell culture supernate

Vascular endothelial growth factor c promotes ovarian carcinoma progression through paracrine and autocrine mechanisms.
Authors: Decio A, Taraboletti G, Patton V, Alzani R, Perego P, Fruscio R, Jurgensmeier J, Giavazzi R, Belotti D
Am J Pathol, 2014;184(4):1050-61.
Species: Human
Sample Type: Ascites

Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer.
Authors: Armstrong A, Haggman M, Stadler W, Gingrich J, Assikis V, Polikoff J, Damber J, Belkoff L, Nordle O, Forsberg G, Carducci M, Pili R
Clin Cancer Res, 2013;19(24):6891-901.
Species: Human
Sample Type: Plasma

Lysophosphatidic Acid Enhances Vascular Endothelial Growth Factor-C Expression in Human Prostate Cancer PC-3 Cells.
Authors: Lin CE, Chen SU, Lin CC
PLoS ONE, 2012;7(7):e41096.
Species: Human
Sample Type: Cell Culture Supernates

Co-expression of alpha9beta1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.
Authors: Majumder M, Tutunea-Fatan E, Xin X, Rodriguez-Torres M, Torres-Garcia J, Wiebe R, Timoshenko AV, Bhattacharjee RN, Chambers AF, Lala PK
PLoS ONE, 2012;7(4):e35094.
Species: Human
Sample Type: Cell Culture Supernates

Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis.
Authors: Yazdani S, Poosti F, Kramer A, Mirkovic K, Kwakernaak A, Hovingh M, Slagman M, Sjollema K, de Borst M, Navis G, van Goor H, van den Born J
PLoS ONE, 2012;7(11):e50209.
Species: Human
Sample Type: Cell Culture Supernates

Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib.
Authors: Harmon CS, DePrimo SE, Raymond E, Cheng AL, Boucher E, Douillard JY, Lim HY, Kim JS, Lechuga MJ, Lanzalone S, Lin X, Faivre S
J Transl Med, 2011;9(0):120.
Species: Human
Sample Type: Plasma

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.
Authors: Scheel C, Eaton E, Li S, Chaffer C, Reinhardt F, Kah K, Bell G, Guo W, Rubin J, Richardson A, Weinberg R
Cell, 2011;145(6):926-40.
Species: Human
Sample Type: Cell culture supernatant

Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2589-95.
Species: Human
Sample Type: Serum

Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
Authors: Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS
Biol. Reprod., 2010;83(1):27-35.
Species: Human
Sample Type: Cell Culture Supernates

Phase I and pharmacological study of the broad-spectrum tyrosine kinase inhibitor JNJ-26483327 in patients with advanced solid tumours.
Authors: Konings IR, de Jonge MJ, Burger H
Br. J. Cancer, 2010;103(7):987-92.
Species: Human
Sample Type: Serum

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Authors: Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Muller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, Van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J
Nat. Med., 2009;15(5):545-52.
Species: Human
Sample Type: Serum

VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B.
Authors: Onimaru M, Yonemitsu Y, Fujii T, Tanii M, Nakano T, Nakagawa K, Kohno R, Hasegawa M, Nishikawa S, Sueishi K
Am. J. Physiol. Heart Circ. Physiol., 2009;297(5):H1685-96.
Species: Human
Sample Type: Serum

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Authors: Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK
J. Clin. Oncol., 2009;27(18):3027-35.
Species: Human
Sample Type: Plasma

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates

Cutting edge: rapid accumulation of epidermal CCL27 in skin-draining lymph nodes following topical application of a contact sensitizer recruits CCR10-expressing T cells.
Authors: Huang V, Lonsdorf AS, Fang L, Kakinuma T, Lee VC, Cha E, Zhang H, Nagao K, Zaleska M, Olszewski WL, Hwang ST
J. Immunol., 2008;180(10):6462-6.
Species: Human
Sample Type: Serum

Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma.
Authors: Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ
J. Clin. Oncol., 2008;26(22):3743-8.
Species: Human
Sample Type: Plasma

Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines.
Authors: Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI, Kirkpatrick CJ
Int. J. Oncol., 2008;32(3):585-92.
Species: Human
Sample Type: Cell Culture Supernates

Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
Authors: Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U
Stem Cells, 2007;25(8):1862-71.
Species: Human
Sample Type: Cell Culture Supernates

Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
Authors: Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte L, Alitalo K
Cancer Res., 2007;67(2):593-9.
Species: Human
Sample Type: Cell Culture Supernates

Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia.
Authors: Lee CY, Tien HF, Hu CY, Chou WC, Lin LI
Br. J. Cancer, 2007;97(7):877-82.
Species: Human
Sample Type: Plasma

Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor.
Authors: Lin J, Lalani AS, Harding TC
Cancer Res., 2005;65(15):6901-9.
Species: Human
Sample Type: Tissue Homogenates

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a VEGF subfamily that shares the conserved VEGF homology domain (VHD) with other VEGF family members, but is distinguished by their preferential formation of non-covalent homodimers. VEGF-C (Cys156Ser) is a selective agonist of VEGF R3 and does not bind VEGF R2 (Joukov, V. et. al., 1998, J. Biol. Chem. 273:6599).
运输条件Blue Ice
存放说明4℃
参考文献
  • ICC / IHC Images: VEGF-C
  • Mini-review: Vascular Endothelial Growth Factor (VEGF)
  • Proliferation Bioassay HUVECs
  • VEGF Family
  • VEGF Family Ligands