Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass.
Authors: Jongman R, van Klarenbosch J, Molema G, Zijlstra J, de Vries A, van Meurs M
PLoS ONE, 2015;10(8):e0136205.
Species: Human
Sample Type: Plasma

Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases.
Authors: Wertenbroek, Marieke, Schepers, Marianne, Kamminga-Rasker, Hannetta, Bottema, Jan T, Muller Kobold, Anneke C, Roelofsen, Han, de Jong, Koert P
BMC Cancer, 2013;13(1):266.
Species: Human
Sample Type: Serum

Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study.
Authors: Rasul S, Reiter MH, Ilhan A, Lampichler K, Wagner L, Kautzky-Willer A
Cardiovasc Diabetol, 2011;10(0):55.
Species: Human
Sample Type: Plasma

Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF.
Authors: Boucherat O, Franco-Montoya ML, Delacourt C, Martinovic J, Masse V, Elie C, Thebaud B, Benachi A, Bourbon JR
Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(6):L849-56.
Species: Human
Sample Type: Tissue Homogenates

Shedding of the endothelial receptor tyrosine kinase Tie2 correlates with leukemic blast burden and outcome after allogeneic hematopoietic stem cell transplantation for AML.
Authors: Koenecke C, Kumpers P, Lukasz A, Dammann E, Verhagen W, Gohring G, Buchholz S, Krauter J, Eder M, Schlegelberger B, Ganser A
Ann. Hematol., 2010;89(5):459-67.
Species: Human
Sample Type: Serum

Changes in vascular endothelial growth factor, angiopoietins, and Tie-2 levels with G-CSF stimulation in healthy donors.
Authors: Serefhanoglu S, Goker H, Buyukasik Y, Turgut M, Sayinalp N, Haznedaroglu IC, Aksu S, Akman U, Ozcebe OI
Ann. Hematol., 2009;88(7):667-71.
Species: Human
Sample Type: Plasma

The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy.
Authors: Cai J, Kehoe O, Smith GM, Hykin P, Boulton ME
Invest. Ophthalmol. Vis. Sci., 2008;49(5):2163-71.
Species: Bovine
Sample Type: Cell Lysates

Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia.
Authors: Lee CY, Tien HF, Hu CY, Chou WC, Lin LI
Br. J. Cancer, 2007;97(7):877-82.
Species: Human
Sample Type: Plasma

Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients.
Authors: Caine GJ, Ryan P, Lip GY, Blann AD
Cancer Lett., 2007;251(2):296-301.
Species: Human
Sample Type: Plasma

Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
Cancer Lett., 2007;248(1):131-6.
Species: Human
Sample Type: Plasma

Circulating levels of total angiopoietin-2 and the soluble Tie-2 receptor in women during ovarian stimulation and early gestation.
Authors: Molskness TA, Stouffer RL, Burry KA, Gorrill MJ, Lee DM, Patton PE
Fertil. Steril., 2006;86(5):1531-3.
Species: N/A
Sample Type:

Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers.
Authors: Niedzwiecki S, Stepien T, Kopec K, Kuzdak K, Komorowski J, Krupinski R, Stepien H
Cytokine, 2006;36(5):291-5.
Species: Human
Sample Type: Serum

Differential levels of soluble angiopoietin-2 and Tie-2 in patients with haematological malignancies.
Authors: Quartarone E, Alonci A, Allegra A, Bellomo G, Calabro L, DAngelo A, Del Fabro V, Grasso A, Cincotta M, Musolino C
Eur. J. Haematol., 2006;77(6):480-5.
Species: Human
Sample Type: Serum

Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease.
Authors: Koutroubakis IE, Xidakis C, Karmiris K, Sfiridaki A, Kandidaki E, Kouroumalis EA
Eur. J. Clin. Invest., 2006;36(2):127-32.
Species: Human
Sample Type: Serum

Differential expression of angiopoietin-1, angiopoietin-2, and Tie receptors in placentas from pregnancies complicated by placenta accreta.
Authors: Tseng JJ, Hsu SL, Ho ES, Hsieh YT, Wen MC, Chou MM
Am. J. Obstet. Gynecol., 2006;194(2):564-71.
Species: Human
Sample Type: Tissue Homogenates

Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours.
Authors: Mross K, Drevs J, Muller M, Medinger M, Marme D, Hennig J, Morgan B, Lebwohl D, Masson E, Ho YY, Gunther C, Laurent D, Unger C
Eur. J. Cancer, 2005;41(9):1291-9.
Species: Human
Sample Type: Serum

Multiple roles for the receptor tyrosine kinase axl in tumor formation.
Authors: Holland SJ, Powell MJ, Franci C, Chan EW, Friera AM, Atchison RE, McLaughlin J, Swift SE, Pali ES, Yam G, Wong S, Lasaga J, Shen MR, Yu S, Xu W, Hitoshi Y, Bogenberger J, Nör JE, Payan DG, Lorens JB
Cancer Res., 2005;65(20):9294-303.
Species: Human
Sample Type: Cell Lysates

Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model.
Authors: Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G
Biochem. Biophys. Res. Commun., 2004;322(2):684-92.
Species: Human
Sample Type: Cell Culture Supernates

Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.

Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

• Angiopoietins, Angiopoietin-like Proteins, and Receptors
• Endothelial Cell Differentiation Markers
• Endothelial Cell Markers
• Endothelial Progenitor and Endothelial Cell Markers
• Endothelial Progenitor Cell Markers
• Hemangioblasts
• Human CD Marker Products
• ICC / IHC Images: Tie-2
• Receptor Tyrosine Kinases (RTKs)
• Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
• Receptors in the Jak/STAT Pathway
• The Search for Tie-1 and Tie-2 Ligands