Human Sonic Hedgehog/Shh N-Terminus Quantikine ELISA Kit (1 KT)
货号：
DSHH00 基本售价：
7356.5 元 规格：
1 Kit
产品信息
概述| 货号 | DSHH00 |
| 描述 | The Quantikine Human Sonic Hedgehog/Shh N-Terminus Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Shh-N in cell culture supernates, serum, and heparin plasma. It contains E. coli-expressed recombinant human Shh-N and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Shh-N showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Shh-N. |
| 别名 | HHG1; HHG-1; HLP3; HPE3; MCOPCB5sonic hedgehog (Drosophila) homolog; Shh; SMMCIsonic hedgehog homolog (Drosophila); sonic hedgehog homolog; sonic hedgehog protein; sonic hedgehog; TPT; TPTPS; |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 6469 (Human); 20423 (Mouse) |
| 生物活性 | Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested. |
| 背景 | Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - A Role for Sonic Hedgehog in Axon Guidance
- Axon Guidance and Neuron Migration
- EMT Induction
- Hedgehog Family
- Hedgehogs
- ICC / IHC Images: Sonic Hedgehog/Shh
- Lipid-modified Sonic Hedgehog (Shh)
- Mini-review: Sonic Hedgehog (Shh)
- Morphogens
- Retinal Stem Cell Markers
- Sonic Hedgehog: a morphogen involved in axon guidance
|
