| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.
Authors: Amer A, Probert P, Dunn M, Knight M, Vallance A, Flecknell P, Oakley F, Cameron I, White S, Blain P, Wright M
PLoS ONE, 2015;10(8):e0136173.
Species: Rat
Sample Type: Serum
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Authors: Rai S, Nejadhamzeeigilani Z, Gutowski N, Whatmore J
J Exp Clin Cancer Res, 2015;34(0):105.
Species: Human
Sample Type: Cell Culture Supernates
Identification of aortic arch-specific quantitative trait loci for atherosclerosis by an intercross of DBA/2J and 129S6 apolipoprotein E-deficient mice.
Authors: Kayashima Y, Makhanova N, Matsuki K, Tomita H, Bennett B, Maeda N
PLoS ONE, 2015;10(2):e0117478.
Species: Mouse
Sample Type: Plasma
Prognostic impact of hyaluronan and its regulators in pancreatic ductal adenocarcinoma.
Authors: Cheng, Xiao-Bo, Sato, Norihiro, Kohi, Shiro, Yamaguchi, Koji
PLoS ONE, 2013;8(11):e80765.
Species: Human
Sample Type: Tissue Lysate
Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein.
Authors: Yuan, Han, Tank, Mihir, Alsofyani, Abeer, Shah, Naman, Talati, Nishant, LoBello, Jaclyn C, Kim, Jin Ryou, Oonuki, Yoji, de la Motte, Carol A, Cowman, Mary K
Glycobiology, 2013;23(11):1270-80.
Species: not specified
Sample Type: hyaluronan
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| 背景 | Hyaluronan, also known as hyaluronic acid (HA) or sodium hyaluronate, is a naturally occurring linear polymer. Hyaluronan is a glycosaminoglycan (GAG) that is ubiquitously present in the extracellular matrix of all vertebrates and is also present in the capsule of some strains of Streptococci. Mammalian hyaluronan is synthesized by one of three distinct hyaluronan synthases (HAS1, 2, and 3), which produce HA polymers with different chain lengths and differ in their rates of synthesis. Whereas high molecular weight HA (> 500 kDa) is anti-angiogenic, anti-inflammatory and immunosuppressive, low molecular weight HA (10 - 500 kDa) is highly angiogenic and pro-inflammatory. HA oligomers are anti-apoptotic and upregulate heat shock protein expression. Functionally, hyaluronan molecules are important for the maintenance of a highly hydrated extracellular matrix in tissues, which is involved in cell adhesion and supports cell migration. |
