| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Urokinase receptor mediates osteoclastogenesis via M-CSF release from osteoblasts and the c-Fms/PI3K/Akt/NF-kappaB pathway in osteoclasts.
Authors: Kalbasi Anaraki P, Patecki M, Tkachuk S, Kiyan Y, Haller H, Dumler I
J Bone Miner Res, 2015;30(2):379-88.
Species: Human
Sample Type: cell supernates
Induced osteoclastogenesis by fluoroquinolones in unstimulated and stimulated human osteoclast precursor cells.
Authors: Costa-Rodrigues J, Martins EG, Fernandes MH
Bone, 2012;51(1):17-27.
Species: Human
Sample Type: Cell Culture Supernates
Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
Authors: Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
Blood, 2012;120(19):4058-67.
Species: Human
Sample Type: Serum
Whole-Body UVB Irradiation during Allogeneic Hematopoietic Cell Transplantation Is Safe and Decreases Acute Graft-versus-Host Disease.
Authors: Kreutz M, Karrer S, Hoffmann P
J. Invest. Dermatol., 2012;132(1):179-87.
Species: Human
Sample Type: Serum
Hypoxia potentiates glioma-mediated immunosuppression.
Authors: Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB
PLoS ONE, 2012;6(1):e16195.
Species: Human
Sample Type: Cell Culture Supernates
Circulating level of macrophage colony-stimulating factor can be predictive for human in vitro fertilization outcome.
Authors: Salmassi A, Mettler L, Jonat W
Fertil. Steril., 2010;93(1):116-23.
Species: Human
Sample Type: Serum
EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation.
Authors: Seizer P, Schonberger T, Schott M, Lang MR, Langer HF, Bigalke B, Kramer BF, Borst O, Daub K, Heidenreich O, Schmidt R, Lindemann S, Herouy Y, Gawaz M, May AE
Atherosclerosis, 2010;209(1):51-7.
Species: Human
Sample Type: Cell Culture Supernates
HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
J. Exp. Med., 2009;206(1):169-81.
Species: Human
Sample Type: Cell Culture Supernates
Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates
Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide.
Authors: Dower K, Ellis DK, Saraf K, Jelinsky SA, Lin LL
J. Immunol., 2008;180(5):3520-34.
Species: Human
Sample Type: Cell Culture Supernates
Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells.
Authors: Laudanski K, De A, Miller-Graziano C
Eur. J. Immunol., 2007;37(10):2812-24.
Species: Human
Sample Type: Cell Culture Supernates
Markers of immune activation and viral load in HIV-associated sensory neuropathy.
Authors: Schifitto G, McDermott MP, McArthur JC, Marder K, Sacktor N, McClernon DR, Conant K, Cohen B, Epstein LG, Kieburtz K, Kieburtz K
Neurology, 2005;64(5):842-8.
Species: Human
Sample Type: Plasma
The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice.
Authors: Ovadia S, Insogna K, Yao GQ
Biol. Reprod., 2005;74(2):331-6.
Species: Human
Sample Type: Tissue Homogenates
The effect of inflammatory cytokines on secretion of macrophage colony-stimulating factor and monocyte chemoattractant protein-1 in human granulosa cells.
Authors: Kawano Y, Fukuda J, Itoh H, Takai N, Nasu K, Miyakawa I
Am. J. Reprod. Immunol., 2004;52(2):124-8.
Species: Human
Sample Type: Follicular Fluid
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.
Authors: Henkel JS, Engelhardt JI, Siklos L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH
Ann. Neurol., 2004;55(2):221-35.
Species: Human
Sample Type: CSF
Distinct hematopoietic support by two human stromal cell lines.
Authors: Loeuillet C, Bernard G, Remy-Martin J, Saas P, Herve P, Douay L, Chalmers D
Exp. Hematol., 2001;29(6):736-45.
Species: Human
Sample Type: Cell Culture Supernates
High macrophage-colony stimulating factor levels in synovial fluid of loose artificial hip joints.
Authors: Takei I, Takagi M, Ida H, Ogino T, Santavirta S, Konttinen YT
J. Rheumatol., 2000;27(4):894-9.
Species: Human
Sample Type: Synovial Fluid
|
| 背景 | M-CSF, also known as CSF-1, is a four-alpha-helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen. Shorter transcripts encode M-CSF that lack cleavage and PG sites and produce an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer. Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific. |
