Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome.
Authors: Nikolajuk A, Kowalska I, Karczewska-Kupczewska M, Adamska A, Otziomek E, Wolczynski S, Kinalska I, Gorska M, Straczkowski M
Diabetes, 2010;59(4):1026-9.
Species: Human
Sample Type: Serum

Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring.
Authors: Holmlund U, Amoudruz P, Johansson MA, Haileselassie Y, Ongoiba A, Kayentao K, Traore B, Doumbo S, Schollin J, Doumbo O, Montgomery SM, Sverremark-Ekstrom E
Clin. Exp. Immunol., 2010;162(3):500-9.
Species: Human
Sample Type: Milk

Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease.
Authors: Perez-Andres M, Almeida J, Martin-Ayuso M, De Las Heras N, Moro MJ, Martin-Nunez G, Galende J, Cuello R, Abuin I, Moreno I, Dominguez M, Hernandez J, Mateo G, San Miguel JF, Orfao A
Int. J. Cancer, 2009;124(2):367-75.
Species: Human
Sample Type: Plasma

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Authors: Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA
Arthritis Rheum., 2006;54(5):1662-72.
Species: Human
Sample Type: Serum

Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.
Authors: Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K
Heart Vessels, 2004;19(5):237-41.
Species: Human
Sample Type: Plasma

Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation.
Authors: Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS
J. Virol., 2003;77(3):1727-37.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Serum

Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Authors: Erices A, Conget P, Rojas C, Minguell JJ
Exp. Cell Res., 2002;280(1):24-32.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130.
Authors: Stubner S, Schon T, Padberg F, Teipel SJ, Schwarz MJ, Haslinger A, Buch K, Dukoff R, Lasser R, Moller N, Sunderland T, Rapoport SI, Moller HJ, Hampel H
Neurosci. Lett., 1999;259(3):145-8.
Species: Human
Sample Type: CSF

Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimers disease.
Authors: Hampel H, Teipel SJ, Padberg F, Haslinger A, Riemenschneider M, Schwarz MJ, Kotter HU, Scheloske M, Buch K, Stubner S, Dukoff R, Lasser R, Moller N, Sunderland T, Rapoport SI, Moller HJ
Brain Res., 1999;823(1):104-12.
Species: Human
Sample Type: CSF

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.

• Cytokines and Receptors in Allergy and Asthma
• Cytokines and Receptors in Angiogenesis
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• Diabetes
• Human CD Marker Products
• ICC / IHC Images: gp130
• IL-12 Family
• IL-6 Family
• Mini-review: Interleukin 6
• Myeloid-derived Suppressor Cells (MDSC)
• Obesity
• Receptors in the Jak/STAT Pathway
• T Cell Cytokine Signaling
• Th1 Cells
• Th17 Cells
• VPS10P-domain Family