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Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit (1 KT)

货号: DCX130 基本售价: 7217.7 元 规格: 1 Kit

产品信息

概述
货号DCX130
描述The Quantikine Human BLC/BCA-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BLC/BCA-1 in cell culture supernates, serum, plasma, and saliva. It contains E. coli-expressed recombinant human BLC/BCA-1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BLC/BCA-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring BLC/BCA-1.
别名ANGIE; ANGIE2; B cell-attracting chemokine 1; B lymphocyte chemoattractant; BCA-1; BCA1B-cell chemoattractant; BCA-1CXC chemokine BLC; B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); BLC; BLCSmall-inducible cytokine B13; BLR1L; B-lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); chemokine (C-X-C motif) ligand 13; C-X-C motif chemokine 13; SCYB13B-cell-attracting chemokine 1; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant);
反应种属Human
目标/特异性Natural and recombinant human BLC/BCA-1
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
10563 (Human); 55985 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial).
Authors: Epeldegui M, Lee J, Martinez A, Widney D, Magpantay L, Regidor D, Mitsuyasu R, Sparano J, Ambinder R, Martinez-Maza O
Clin Cancer Res, 2016;22(2):328-36.
Species: Human
Sample Type: Plasma

Biomarkers of inflammation and axonal degeneration/damage in patients with newly diagnosed multiple sclerosis: contributions of the soluble CD163 CSF/serum ratio to a biomarker panel.
Authors: Stilund M, Gjelstrup M, Petersen T, Moller H, Rasmussen P, Christensen T
PLoS ONE, 2015;10(4):e0119681.
Species: Human
Sample Type: Serum

HIV-1 single-stranded RNA induces CXCL13 secretion in human monocytes via TLR7 activation and plasmacytoid dendritic cell-derived type I IFN.
Authors: Cohen K, Dugast A, Alter G, McElrath M, Stamatatos L
J Immunol, 2015;194(6):2769-75.
Species: Human
Sample Type: Plasma

Cerebrospinal Fluid Neopterin as Marker of the Meningo-Encephalitic Stage of Trypanosoma brucei gambiense Sleeping Sickness.
Authors: Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru JC, Robin X, Turck N, Kristensson K, Ngoyi DM, Vatunga GM, Krishna S, Buscher P, Bisser S, Ndungu JM, Sanchez JC
PLoS ONE, 2012;7(7):e40909.
Species: Human
Sample Type: CSF

The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS).
Authors: Brettschneider J, Czerwoniak A, Senel M
PLoS ONE, 2010;5(8):e11986.
Species: Human
Sample Type: Serum

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
Authors: Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW
Cancer Lett., 2009;283(1):29-35.
Species: Human
Sample Type: Serum

Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.
Authors: Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, Draghici S, Gotsch F, Kusanovic JP, Hassan SS, Kim JS
J. Immunol., 2009;182(6):3919-27.
Species: Human
Sample Type: Plasma

Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor.
Authors: Rioja I, Hughes FJ, Sharp CH, Warnock LC, Montgomery DS, Akil M, Wilson AG, Binks MH, Dickson MC
Arthritis Rheum., 2008;58(8):2257-67.
Species: Human
Sample Type: Plasma

Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis.
Authors: Sansonno D, Tucci FA, Troiani L, Lauletta G, Montrone M, Conteduca V, Sansonno L, Dammacco F
Blood, 2008;112(5):1620-7.
Species: Human
Sample Type: Serum

Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.
Authors: Cagigi A, Mowafi F, Phuong Dang LV, Tenner-Racz K, Atlas A, Grutzmeier S, Racz P, Chiodi F, Nilsson A
Blood, 2008;112(12):4401-10.
Species: Human
Sample Type: Cell Culture Supernates

Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients.
Authors: Panse J, Friedrichs K, Marx A, Hildebrandt Y, Luetkens T, Bartels K, Horn C, Stahl T, Cao Y, Milde-Langosch K, Niendorf A, Kroger N, Wenzel S, Leuwer R, Bokemeyer C, Hegewisch-Becker S, Atanackovic D
Br. J. Cancer, 2008;99(6):930-8.
Species: Human
Sample Type: Serum

Lymphoid chemokines in chronic neuroinflammation.
Authors: Aloisi F, Columba-Cabezas S, Franciotta D, Rosicarelli B, Magliozzi R, Reynolds R, Ambrosini E, Coccia E, Salvetti M, Serafini B
J. Neuroimmunol., 2008;198(1):106-12.
Species: Human
Sample Type: CSF

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.
Authors: Burkle A, Niedermeier M, Schmitt-Graff A, Wierda WG, Keating MJ, Burger JA
Blood, 2007;110(9):3316-25.
Species: Human
Sample Type: Serum

Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
Authors: Lim HW, Kim CH
J. Immunol., 2007;179(11):7448-56.
Species: Human
Sample Type: Cell Culture Supernates

High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis.
Authors: Shin JJ, Glickstein LJ, Steere AC
Arthritis Rheum., 2007;56(4):1325-35.
Species: Human
Sample Type: Synovial Fluid

Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts.
Authors: Munoz-Fernandez R, Blanco FJ, Frecha C, Martin F, Kimatrai M, Abadia-Molina AC, Garcia-Pacheco JM, Olivares EG
J. Immunol., 2006;177(1):280-9.
Species: Human
Sample Type: Cell Culture Supernates

IL1beta and TNFalpha differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: evidence of changes associated to cell maturation.
Authors: Lisignoli G, Cristino S, Toneguzzi S, Grassi F, Piacentini A, Cavallo C, Facchini A, Mariani E
Exp. Gerontol., 2004;39(4):659-65.
Species: Human
Sample Type: Cell Culture Supernates

Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
Authors: Casazza S, Zappia E, Pistorio A, Gambini C
Proc. Natl. Acad. Sci. U.S.A., 2004;101(30):11064-9.
Species: Human
Sample Type: CSF

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Authors: Lim HW, Hillsamer P, Kim CH
J. Clin. Invest., 2004;114(11):1640-9.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It can form homodimers or heterodimers with FGF basic, and it signals through CXCR3 or CXCR5. CXCL13 induces the migration of naïve B cells and a subset of memory T cells to lymphoid tissue. It also promotes B1 cell migration into the omentum and peritoneum. In the fetus, CXCL13 attracts CD4+ CD3- IL-7 R alpha+ hematopoietic cells to sites of future Peyer’s patch development.
运输条件Blue Ice
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参考文献
  • B Cell Chemotaxis, Migration, and Adhesion
  • Chemokines and Receptors
  • Chemokines and Receptors in Angiogenesis
  • Chemokines and Receptors in Tfh Cell Differentiation and Function
  • CXC Chemokines and Receptors
  • gamma delta T Cells
  • ICC / IHC Images: CXCL13/BLC/BCA-1
  • Macrophage Activation Markers