Human CD40 Quantikine ELISA Kit (1 KT)
货号：
DCCD40 基本售价：
7217.7 元 规格：
1 Kit
产品信息
概述| 货号 | DCCD40 |
| 描述 | The Quantikine Human CD40 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CD40 in cell culture supernates, serum, plasma, saliva, urine, and human milk. It contains NS0-expressed recombinant human CD40 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CD40 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CD40. |
| 别名 | B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5; |
| 反应种属 | Human |
| 目标/特异性 | Natural and recombinant human CD40 |
性能| 供应商 | R&D Systems |
| 检测类型 | Solid Phase Sandwich ELISA |
| Entrez Gene IDs | 958 (Human); 21939 (Mouse); 171369 (Rat); 102118696 (Cynomolgus Monkey) |
| 生物活性 | < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested. |
| 背景 | CD40, also known as TNFRSF5, is a transmembrane TNF superfamily receptor that is expressed on the surface of B cells, dendritic cells, macrophages, monocytes and platelets, as well as endothelial and epithelial cells. Interaction of CD40 with CD40 Ligand leads to the aggregation of CD40 molecules resulting in the initiation of bidirectional intracellular signaling in both CD40 and CD40 Ligand expressing cells. This interaction promotes B cell activation and T cell-dependent humoral responses. CD40 serves multiple functions in both hematopoietic and epithelial cancers and is a target for tumor immunotherapy. Dysregulation of CD40/CD40 Ligand expression and interactions contributes to disease severity in AIDS, atherosclerosis, atherothrombosis, and restenosis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - B Cell Activation
- B Cell Markers
- Co-stimulatory and Co-inhibitory Molecules
- Co-stimulatory Molecules Associated with Tfh Cells
- Dendritic Cell Co-stimulatory Molecules
- Dendritic Cell Development
- gamma delta T Cells
- Human CD Marker Products
- ICC / IHC Images: CD40/TNFRSF5
- Multiple Myeloma
- Myeloid-derived Suppressor Cells (MDSC)
- Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
- Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
- Regulation of T Cell Co-stimulation by TNF Superfamily Members
- Regulatory T Cells (Tregs)
- TNF Superfamily
- TNF Superfamily Receptors
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