Human CCL27/CTACK Quantikine ELISA Kit (1 KT)【科瑞奥博】

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Human CCL27/CTACK Quantikine ELISA Kit (1 KT)

货号： DCC270 基本售价： 7217.7 元规格： 1 Kit

产品信息

概述
货号	DCC270
描述	The Quantikine Human CTACK Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CTACK in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human CTACK and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CTACK showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring CTACK.
别名	ALP; C-C motif chemokine 27; chemokine (C-C motif) ligand 27; CTACK; CTACKSmall-inducible cytokine A27; CTAK; cutaneous T-cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESKINE; IL-11 Ralpha-locus chemokine; ILC; ILCCC chemokine ILC; PESKY; SCYA27IL-11 R-alpha-locus chemokine; skinkine; small inducible cytokine subfamily A (Cys-Cys), member 27;
反应种属	Human
目标/特异性	Natural and recombinant human CTACK

性能
供应商	R&D Systems
检测类型	Solid Phase Sandwich ELISA
Entrez Gene IDs	10850 (Human); 20301 (Mouse); 362505 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Phenotypic characterization of leukocytes in prenatal human dermis. J. Invest. Dermatol., 2012;132(11):2581-92. Species: Human Sample Type: Cell Culture Supernates Serum and tissue CTACK/CCL27 chemokine levels in early mycosis fungoides may be correlated with disease-free survival following treatment with interferon alfa and psoralen plus ultraviolet A therapy. Authors: Goteri G, Rupoli S, Campanati A, Zizzi A, Picardi P, Cardelli M, Giantomassi F, Canafoglia L, Marchegiani F, Mozzicafreddo G, Brandozzi G, Stramazzotti D, Ganzetti G, Lisa R, Simonetti O, Offidani A, Federici I, Filosa G, Leoni P Br. J. Dermatol., 2012;166(5):948-52. Species: Human Sample Type: Serum Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. Authors: Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY J. Allergy Clin. Immunol., 2009;124(2):260-9, 269.e1. Species: Human Sample Type: Serum The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis. Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P Mediators Inflamm., 2009;2009(0):269541. Species: Human Sample Type: Serum Cutting edge: rapid accumulation of epidermal CCL27 in skin-draining lymph nodes following topical application of a contact sensitizer recruits CCR10-expressing T cells. Authors: Huang V, Lonsdorf AS, Fang L, Kakinuma T, Lee VC, Cha E, Zhang H, Nagao K, Zaleska M, Olszewski WL, Hwang ST J. Immunol., 2008;180(10):6462-6. Species: Human Sample Type: Serum Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells. Authors: Wick N, Haluza D, Gurnhofer E, Raab I, Kasimir MT, Prinz M, Steiner CW, Reinisch C, Howorka A, Giovanoli P, Buchsbaum S, Krieger S, Tschachler E, Petzelbauer P, Kerjaschki D Am. J. Pathol., 2008;173(4):1202-9. Species: Human Sample Type: Cell Culture Supernates Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. Authors: Sasaki M, Honda A, Furuichi M, Norisugi O Clin. Cancer Res., 2006;12(9):2670-5. Species: Human Sample Type: Serum Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Authors: Hon KL, Leung TF, Ma KC, Li AM, Wong Y, Fok TF Clin. Exp. Dermatol., 2004;29(3):293-6. Species: Human Sample Type: Serum
生物活性	< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景	CCL27, also known as Cutaneous T cell-attracting chemokine (CTACK), ALP, ILC and ESkine, is a CC chemokine discovered using expressed sequence tags (EST) in a homology search for novel chemokines. Mature human and mouse CCL27 are 84% similar. Mouse CCL27 shares 37% and 35% amino acid identity with mouse MIP-3 beta and mouse TECK, respectively. CCL27 is predominantly expressed in the skin. The expression is up-regulated by proinflammatory cytokines.
运输条件	Blue Ice
存放说明	4℃
参考文献	CC Chemokines and Receptors Chemokines and Receptors ICC / IHC Images: CCL27/CTACK Mini-review: Chemokines III