| 货号 | DCATB0 |
| 描述 | The Quantikine Human Pro-Cathepsin B Immunoassay is a 4.5 hour solid phase ELISA designed to measure the pro-form of cathepsin B in cell culture supernates, cell lysates, serum, plasma, saliva, and urine. It contains NS0-expressed recombinant human Pro-Cathepsin B and antibodies raised against the recombinant factor. Natural human Pro-Cathepsin B showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human Pro-Cathepsin B. |
| 别名 | APP secretase; APPS; cathepsin B; Cathepsin B1; CPSBamyloid precursor protein secretase; CTSB; cysteine protease; EC 3.4.22; EC 3.4.22.1; |
| 反应种属 | Human |
| 目标/特异性 | Natural and recombinant human Pro-Cathepsin B |
| 供应商 | R&D Systems |
| 检测类型 | Solid Phase Sandwich ELISA |
| Entrez Gene IDs | 1508 (Human); 13030 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. | |
| 生物活性 | Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested. |
| 背景 | Cathepsin B is the first described member of the family of lysosomal cysteine proteases. Cathepsin B possesses both endopeptidase and exopeptidase activities, in the latter case acting as a peptidyl-dipeptidase. It is known to process a number of proteins, including pro and active caspases, prorenin and SLPI. Cathepsin B is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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