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Kit, Human Fas Ligand/TNFSF6 Quantikine ELISA 2nd Gen ( )

货号: DFL00B 基本售价: 6791.4 元 规格: 1 KT

产品信息

概述
货号DFL00B
描述The Quantikine® Human Fas Ligand/TNFSF6 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Fas Ligand in cell culture supernates, cell lysates, serum, and plasma. It contains CHO cell-expressed recombinant human Fas Ligand and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Fas Ligand showed linear curves that were parallel to the standard curves obtained using the Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for natural human Fas Ligand.
别名
apoptosis (APO-1) antigen ligand 1; Apoptosis antigen ligand; APT1LG1CD95L; APTL; CD178 antigen; CD178; CD95L; CD95-L; Fas antigen ligand; Fas ligand (TNF superfamily, member 6); Fas Ligand; FASLCD95 ligand; FASLG; TNFSF6; TNFSF6FasL; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6
目标/特异性Natural and recombinant human Fas Ligand.
性能
供应商R&D Systems
Entrez Gene IDs
356 (Human); 14103 (Mouse); 25385 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis
Sci Rep, 2016;6(0):36862.
Species: Human
Sample Type: Plasma

Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations.
Authors: Price S, Shaw P, Seitz A, Joshi G, Davis J, Niemela J, Perkins K, Hornung R, Folio L, Rosenberg P, Puck J, Hsu A, Lo B, Pittaluga S, Jaffe E, Fleisher T, Rao V, Lenardo M
Blood, 2014;123(13):1989-99.
Species: Human
Sample Type: Serum

SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death.
Authors: Katz, Gil, Krummey, Scott M, Larsen, Sasha E, Stinson, Jeffrey, Snow, Andrew L
J Immunol, 2014;192(9):4202-9.
Species: Human
Sample Type: Cell Culture Supernates

Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling.
Authors: Beynon V, Quintana FJ, Weiner HL
PLoS ONE, 2012;7(6):e39576.
Species: Human
Sample Type: Serum

Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.
Authors: Tang TT, Zhu ZF, Wang J, Zhang WC, Tu X, Xiao H, Du XL, Xia JH, Dong NG, Su W, Xia N, Yan XX, Nie SF, Liu J, Zhou SF, Yao R, Xie JJ, Jevallee H, Wang X, Liao MY, Shi GP, Fu M, Liao YH, Cheng X
PLoS ONE, 2011;6(9):e24272.
Species: Human
Sample Type: Plasma

Effect of quinapril on in-stent restenosis and relation to plasma apoptosis signaling molecules.
Authors: Deftereos S, Giannopoulos G, Kossyvakis C, Kaoukis A, Raisakis K, Driva M, Panagopoulou V, Lappos S, Rentoukas I, Pyrgakis V, Alpert MA
Am. J. Cardiol., 2010;105(1):54-8.
Species: Human
Sample Type: Plasma

Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome.
Authors: Dowdell KC, Niemela JE, Price S, Davis J, Hornung RL, Oliveira JB, Puck JM, Jaffe ES, Pittaluga S, Cohen JI, Fleisher TA, Rao VK
Blood, 2010;115(25):5164-9.
Species: Human
Sample Type: Plasma

Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus.
Authors: Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V
J. Exp. Med., 2009;206(4):793-805.
Species: Human
Sample Type: Cell Culture Supernates

Differential effects of arsenic on cutaneous and systemic immunity: focusing on CD4+ cell apoptosis in patients with arsenic-induced Bowen's disease.
Authors: Liao WT, Yu CL, Lan CC, Lee CH, Chang CH, Chang LW, You HL, Yu HS
Carcinogenesis, 2009;30(6):1064-72.
Species: Human
Sample Type: Cell Culture Supernates

A 60-s postconditioning protocol by percutaneous coronary intervention inhibits myocardial apoptosis in patients with acute myocardial infarction.
Authors: Zhao WS, Xu L, Wang LF, Zhang L, Zhang ZY, Liu Y, Liu XL, Yang XC, Cui L, Zhang L
Apoptosis, 2009;14(10):1204-11.
Species: Human
Sample Type: Plasma

The influence of hepatic damage on serum soluble Fas ligand levels of patients with drug rashes.
Authors: Tohyama M, Shirakata Y, Sayama K, Hashimoto K
J. Allergy Clin. Immunol., 2009;123(4):971-2; author.
Species: Human
Sample Type: Serum

Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Authors: Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT
Nat. Med., 2008;14(12):1343-50.
Species: Human
Sample Type: Blister Fluid

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates

Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failure.
Authors: Kourea K, Parissis JT, Farmakis D, Panou F, Paraskevaidis I, Venetsanou K, Filippatos G, Kremastinos DT
Atherosclerosis, 2007;199(1):215-21.
Species: Human
Sample Type: Plasma

Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.
Authors: Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D
Carcinogenesis, 2007;28(5):1067-73.
Species: Human
Sample Type: Cell Culture Supernates

Erythropoiesis abnormalities contribute to early-onset anemia in patients with septic shock.
Authors: Claessens YE, Fontenay M, Pene F, Chiche JD, Guesnu M, Hababou C, Casadevall N, Dhainaut JF, Mira JP, Cariou A
Am. J. Respir. Crit. Care Med., 2006;174(1):51-7.
Species: Human
Sample Type: Plasma

Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
Authors: Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS
Am. J. Pathol., 2006;169(5):1863-74.
Species: Human
Sample Type: Cell Culture Supernates

High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction.
Authors: Zhang L, Li YH, Zhang HY, Chen ML, Gao MM, Hu AH, Yang HS
Eur. J. Clin. Invest., 2005;35(3):164-70.
Species: Human
Sample Type: Plasma

Growth hormone-induced reduction of soluble apoptosis mediators is associated with reverse cardiac remodelling and improvement of exercise capacity in patients with idiopathic dilated cardiomyopathy.
Authors: Parissis JT, Adamopoulos S, Karatzas D, Paraskevaidis J, Livanis E, Kremastinos D
Eur J Cardiovasc Prev Rehabil, 2005;12(2):164-8.
Species: Human
Sample Type: Plasma

Vitamin C inhibits platelet expression of CD40 ligand.
Authors: Pignatelli P, Sanguigni V, Paola SG, Lo Coco E, Lenti L, Violi F
Free Radic. Biol. Med., 2005;38(12):1662-6.
Species: Human
Sample Type: Plasma

Escape from cardiomyocyte apoptosis by enterovirus persistence due to elevated soluble Fas-receptors.
Authors: Alter P, Maisch B
Z Kardiol, 2004;93(7):524-32.
Species: Human
Sample Type: Serum

Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway.
Authors: D'Archivio M
FEBS Lett., 2003;540(1):117-24.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
Authors: Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
Mucosal Immunol, 0;5(2):140-9.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells. A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.
运输条件Blue Ice
存放说明4℃
参考文献
  • Epithelial Cell Markers and Intracellular Molecules
  • gamma delta T Cells
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Natural Killer T (NKT) Cells
  • Regulation of Apoptosis by TNF Superfamily Members
  • Surface Ectodermal Cells
  • TNF Superfamily
  • TNF Superfamily Ligands