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Porcine IL-1 beta/IL-1F2 Quantikine ELISA Kit (1 KT)

货号: PLB00B 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号PLB00B
描述The Quantikine Porcine IL-1 beta Immunoassay is a 4.5 hour solid phase ELISA designed to measure porcine IL-1 beta in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mature porcine IL-1 beta and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant porcine IL-1 beta. Results obtained using natural porcine IL-1 beta show dose response curves that are parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural porcine IL-1 beta.
别名catabolin; IL-1 beta; IL-1; IL1B; IL-1B; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta;
全称
Interleukin 1 beta
反应种属Porcine
目标/特异性Natural and recombinant porcine IL-1 beta
性能
供应商R&D Systems
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans.
Authors: Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE
J. Immunol., 2011;187(9):4913-9.
Species: Porcine
Sample Type: Plasma

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.
Authors: McILwain RB, Timpa JG, Kurundkar AR
Lab. Invest., 2010;90(1):128-39.
Species: Porcine
Sample Type: Plasma

Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis.
Authors: Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tonnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P
Crit. Care Med., 2010;38(6):1467-74.
Species: Porcine
Sample Type: Plasma

CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
Authors: Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tonnessen TI, Johansen HT, Castellheim A, Mollnes TE
FASEB J., 2010;24(3):712-22.
Species: Porcine
Sample Type: Plasma

Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
Authors: Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE
Infect. Immun., 2009;77(2):725-32.
Species: Porcine
Sample Type: Whole Blood

Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues.
Authors: Wall R, Ross RP, Shanahan F, OMahony L, OMahony C, Coakley M, Hart O, Lawlor P, Quigley EM, Kiely B, Fitzgerald GF, Stanton C
Am. J. Clin. Nutr., 2009;89(5):1393-401.
Species: Porcine
Sample Type: Cell Culture Supernates

Cardiac Function and the Proinflammatory Cytokine Response After Recovery From Cardiac Arrest in Swine.
Authors: Niemann JT, Rosborough JP, Youngquist S, Shah AP, Lewis RJ, Phan QT, Filler SG
J. Interferon Cytokine Res., 2009;0(0):.
Species: Porcine
Sample Type: Plasma

Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery.
Authors: Kruse R, Essen-Gustavsson B, Fossum C, Jensen-Waern M
Acta Vet. Scand., 2008;50(0):32.
Species: Porcine
Sample Type: Serum

Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model.
Authors: Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE
J. Immunol., 2008;180(9):6346-53.
Species: Porcine
Sample Type: Cell Culture Supernates

Effects of glucocorticoids in ventilated piglets with severe pneumonia.
Authors: Sibila O, Luna CM, Agusti C, Baquero S, Gando S, Patron JR, Morato JG, Absi R, Bassi N, Torres A
Eur. Respir. J., 2008;32(4):1037-46.
Species: Porcine
Sample Type: Serum

The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury.
Authors: Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher D, Wolzt M, Barthuber C, Noldge-Schomburg GE, Scheeren TW, Zacharowski K
Crit. Care Med., 2007;35(7):1730-5.
Species: Porcine
Sample Type: Plasma

Experimental Pseudomonas aeruginosa pneumonia: evaluation of the associated inflammatory response.
Authors: Sibila O, Agusti C, Torres A, Baquero S, Gando S, Patron JR, Morato JG, Goffredo DH, Bassi N, Luna CM
Eur. Respir. J., 2007;30(6):1167-72.
Species: Porcine
Sample Type: Serum

Macrophage transcriptional responses following in vitro infection with a highly virulent African swine fever virus isolate.
Authors: Zhang F, Hopwood P, Abrams CC, Downing A, Murray F, Talbot R, Archibald A, Lowden S, Dixon LK
J. Virol., 2006;80(21):10514-21.
Species: Porcine
Sample Type: Cell Culture Supernates

Effects of therapeutic bronchoalveolar lavage and partial liquid ventilation on meconium-aspirated newborn piglets.
Authors: Jeng MJ, Soong WJ, Lee YS, Chang HL, Shen CM, Wang CH, Yang SS, Hwang B
Crit. Care Med., 2006;34(4):1099-105.
Species: Porcine
Sample Type: Serum

Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.
Authors: Bando T, Morikawa Y, Komori T, Senba E
Neuroscience, 2006;142(4):1263-71.
Species: Porcine
Sample Type: Plasma

Protection against acute porcine lung ischemia/reperfusion injury by systemic preconditioning via hind limb ischemia.
Authors: Waldow T, Alexiou K, Witt W, Albrecht S, Wagner F, Knaut M, Matschke K
Transpl. Int., 2005;18(2):198-205.
Species: Porcine
Sample Type: Plasma

Vitamin E supplementation does not mitigate the acute morbidity effects of porcine reproductive and respiratory syndrome virus in nursery pigs.
Authors: Toepfer-Berg TL, Escobar J, Van Alstine WG, Baker DH, Salak-Johnson J, Johnson RW
J. Anim. Sci., 2004;82(7):1942-51.
Species: Porcine
Sample Type: Serum

Decreased protein accretion in pigs with viral and bacterial pneumonia is associated with increased myostatin expression in muscle.
Authors: Escobar J, Van Alstine WG, Baker DH
J. Nutr., 2004;134(11):3047-53.
Species: Porcine
Sample Type: Serum

Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination.
Authors: Royaee AR, Husmann RJ, Dawson HD, Calzada-Nova G, Schnitzlein WM, Zuckermann FA, Lunney JK
Vet. Immunol. Immunopathol., 2004;102(3):199-216.
Species: Porcine
Sample Type: Cell Culture Supernates

The effect of warm humidified CO2 on the dissipation of residual gas following laparoscopy in piglets.
Authors: Glew PA, Campher MJ, Pearson K, Schofield JC, Davey AK
J Am Assoc Gynecol Laparosc, 2004;11(2):204-10.
Species: Porcine
Sample Type: Serum

Attenuation of reperfusion-induced systemic inflammation by preconditioning with nitric oxide in an in situ porcine model of normothermic lung ischemia.
Authors: Waldow T, Alexiou K, Witt W, Wagner FM, Gulielmos V, Matschke K, Knaut M
Chest, 2004;125(6):2253-9.
Species: Porcine
Sample Type: Plasma

Tumour necrosis factor alpha stimulates nitric oxide production more potently than interleukin-1beta in porcine articular chondrocytes.
Authors: Goodstone NJ, Hardingham TE
Rheumatology (Oxford), 2002;41(8):883-91.
Species: Porcine
Sample Type: Cell Culture Supernates

Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig.
Authors: Yeung JC, Wagnetz D, Cypel M, Rubacha M, Koike T, Chun YM, Hu J, Waddell TK, Hwang DM, Liu M, Keshavjee S
Mol. Ther., 212;20(6):1204-11.
Species: Porcine
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • Chronic IL-1 beta-induced Neuroinflammation Is it Really that Bad?
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • ICC / IHC Images: IL-1 beta/IL-1F2
  • IL-1 Family
  • Infectious Diseases
  • Inflammasomes: Intracellular Regulators of Pathogen
  • Inflammatory Mediators
  • Interactive Pathway: IL-1 Family Signaling Pathways
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Macrophage Activation Markers
  • Mini-review: Interleukin 1
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • NCR-ILC3
  • Neuroinflammation
  • NOD-like Receptors and the Inflammasome
  • Platelets
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th9 Cells