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Porcine IL-6 Quantikine ELISA Kit (1 KT)

货号: P6000B 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号P6000B
描述The Quantikine Porcine IL-6 Immunoassay is a 4.5 hour solid phase ELISA designed to measure porcine IL-6 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant porcine IL-6 and antibodies raised against the recombinant factor. The immunoassay has been shown to accurately quantitate recombinant porcine IL-6. Results obtained using natural porcine IL-6 show dose response curves that are parallel to the standard curves obtained using recombinant Quantikine Porcine IL-6 kit standards. These results indicate that this kit can be used to determine relative mass values for natural porcine IL-6.
别名B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta 2; IFN-beta-2; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A;
全称
Interleukin 6
反应种属Porcine
目标/特异性Natural and recombinant porcine IL-6
性能
供应商R&D Systems
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs.
Authors: Martinez-Olondris P, Rigol M, Soy D, Guerrero L, Agusti C, Quera MA, Li Bassi G, Esperatti M, Luque N, Liapikou M, Filella X, Marco F, de la Bellacasa JP, Torres A
Crit. Care Med., 2012;40(1):162-8.
Species: Porcine
Sample Type: Serum

Mutations in classical swine fever virus NS4B affect virulence in swine.
Authors: Fernandez-Sainz I, Gladue DP, Holinka LG
J. Virol., 2010;84(3):1536-49.
Species: Porcine
Sample Type: Cell Culture Supernates

Comparative measurement of cell-mediated immune responses of swine to the M and N proteins of porcine reproductive and respiratory syndrome virus.
Authors: Jeong HJ, Song YJ, Lee SW
Clin. Vaccine Immunol., 2010;17(4):503-12.
Species: Porcine
Sample Type: Cell Culture Supernates

CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
Authors: Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tonnessen TI, Johansen HT, Castellheim A, Mollnes TE
FASEB J., 2010;24(3):712-22.
Species: Porcine
Sample Type: Plasma

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine.
Authors: McILwain RB, Timpa JG, Kurundkar AR
Lab. Invest., 2010;90(1):128-39.
Species: Porcine
Sample Type: Plasma

Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis.
Authors: Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tonnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P
Crit. Care Med., 2010;38(6):1467-74.
Species: Porcine
Sample Type: Plasma

Cardiac Function and the Proinflammatory Cytokine Response After Recovery From Cardiac Arrest in Swine.
Authors: Niemann JT, Rosborough JP, Youngquist S, Shah AP, Lewis RJ, Phan QT, Filler SG
J. Interferon Cytokine Res., 2009;0(0):.
Species: Porcine
Sample Type: Plasma

Effect of linezolid compared with glycopeptides in methicillin-resistant Staphylococcus aureus severe pneumonia in piglets.
Authors: Luna CM, Bruno DA, Garcia-Morato J, Mann KC, Risso Patron J, Sagardia J, Absi R, Garcia Bottino M, Marchetti D, Famiglietti A, Baleztena M, Biancolini C
Chest, 2009;135(6):1564-71.
Species: Porcine
Sample Type: Serum

Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
Authors: Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE
Infect. Immun., 2009;77(2):725-32.
Species: Porcine
Sample Type: Whole Blood

Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion.
Authors: Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TW, Vollmar B, Noldge-Schomburg GE, Zacharowski K
Crit. Care Med., 2009;37(2):598-605.
Species: Porcine
Sample Type: Plasma

Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery.
Authors: Kruse R, Essen-Gustavsson B, Fossum C, Jensen-Waern M
Acta Vet. Scand., 2008;50(0):32.
Species: Porcine
Sample Type: Serum

Effects of glucocorticoids in ventilated piglets with severe pneumonia.
Authors: Sibila O, Luna CM, Agusti C, Baquero S, Gando S, Patron JR, Morato JG, Absi R, Bassi N, Torres A
Eur. Respir. J., 2008;32(4):1037-46.
Species: Porcine
Sample Type: Serum

Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model.
Authors: Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE
J. Immunol., 2008;180(9):6346-53.
Species: Porcine
Sample Type: Cell Culture Supernates

The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury.
Authors: Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher D, Wolzt M, Barthuber C, Noldge-Schomburg GE, Scheeren TW, Zacharowski K
Crit. Care Med., 2007;35(7):1730-5.
Species: Porcine
Sample Type: Plasma

Sex difference in link between interleukin-6 and stress.
Authors: Jankord R, Turk JR, Schadt JC, Casati J, Ganjam VK, Price EM, Keisler DH, Laughlin MH
Endocrinology, 2007;148(8):3758-64.
Species: Porcine
Sample Type: Plasma

Experimental severe Pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilation.
Authors: Luna CM, Baquero S, Gando S, Patron JR, Morato JG, Sibila O, Absi R, Famiglietti A, Vay CA, Von Stecher F, Agusti C, Torres A
Chest, 2007;132(2):523-31.
Species: Porcine
Sample Type: Serum

Experimental Pseudomonas aeruginosa pneumonia: evaluation of the associated inflammatory response.
Authors: Sibila O, Agusti C, Torres A, Baquero S, Gando S, Patron JR, Morato JG, Goffredo DH, Bassi N, Luna CM
Eur. Respir. J., 2007;30(6):1167-72.
Species: Porcine
Sample Type: Serum

Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.
Authors: Bando T, Morikawa Y, Komori T, Senba E
Neuroscience, 2006;142(4):1263-71.
Species: Porcine
Sample Type: Plasma

A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery.
Authors: Nimjee SM, Keys JR, Pitoc GA, Quick G, Rusconi CP, Sullenger BA
Mol. Ther., 2006;14(3):408-15.
Species: Porcine
Sample Type: Plasma

Effects of therapeutic bronchoalveolar lavage and partial liquid ventilation on meconium-aspirated newborn piglets.
Authors: Jeng MJ, Soong WJ, Lee YS, Chang HL, Shen CM, Wang CH, Yang SS, Hwang B
Crit. Care Med., 2006;34(4):1099-105.
Species: Porcine
Sample Type: Serum

Dietary fatty acid composition rather than vitamin E supplementation influence ex vivo cytokine and eicosanoid response of porcine alveolar macrophages.
Authors: Moller S, Lauridsen C
Cytokine, 2006;35(1):6-12.
Species: Porcine
Sample Type: Cell Culture Supernates

Protection against acute porcine lung ischemia/reperfusion injury by systemic preconditioning via hind limb ischemia.
Authors: Waldow T, Alexiou K, Witt W, Albrecht S, Wagner F, Knaut M, Matschke K
Transpl. Int., 2005;18(2):198-205.
Species: Porcine
Sample Type: Plasma

Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide.
Authors: Changhua L, Jindong Y, Defa L, Lidan Z, Shiyan Q, Jianjun X
J. Nutr., 2005;135(2):239-44.
Species: Porcine
Sample Type: Serum

Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.
Authors: Lauritzen B, Lykkesfeldt J, Djurup R, Flodgaard H, Svendsen O
Pharmacol. Res., 2005;51(6):509-14.
Species: Porcine
Sample Type: Plasma

Standardized lung recruitment during high frequency and conventional ventilation: similar pathophysiologic and inflammatory responses in an animal model of respiratory distress syndrome.
Authors: Krishnan RK, Meyers PA, Worwa C, Goertz R, Schauer G, Mammel MC
Intensive Care Med, 2004;30(6):1195-203.
Species: Porcine
Sample Type: Serum

Adiponectin differentially regulates cytokines in porcine macrophages.
Authors: Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME
Biochem. Biophys. Res. Commun., 2004;316(3):924-9.
Species: Porcine
Sample Type: Cell Culture Supernates

Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells.
Authors: Bensaude E, Turner JL, Wakeley PR, Sweetman DA, Pardieu C, Drew TW, Wileman T, Powell PP
J. Gen. Virol., 2004;85(0):1029-37.
Species: Porcine
Sample Type: Cell Culture Supernates

Decreased protein accretion in pigs with viral and bacterial pneumonia is associated with increased myostatin expression in muscle.
Authors: Escobar J, Van Alstine WG, Baker DH
J. Nutr., 2004;134(11):3047-53.
Species: Porcine
Sample Type: Serum

Attenuation of reperfusion-induced systemic inflammation by preconditioning with nitric oxide in an in situ porcine model of normothermic lung ischemia.
Authors: Waldow T, Alexiou K, Witt W, Wagner FM, Gulielmos V, Matschke K, Knaut M
Chest, 2004;125(6):2253-9.
Species: Porcine
Sample Type: Plasma

Chronic porcine two-hit model with hemorrhagic shock and Pseudomonas aeruginosa sepsis.
Authors: Eissner B, Matz K, Smorodchenko A, Roschmann A, v Specht BU
Eur Surg Res, 2002;34(1):61-7.
Species: Porcine
Sample Type: Plasma

Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig.
Authors: Yeung JC, Wagnetz D, Cypel M, Rubacha M, Koike T, Chun YM, Hu J, Waddell TK, Hwang DM, Liu M, Keshavjee S
Mol. Ther., 212;20(6):1204-11.
Species: Porcine
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Diabetes
  • gamma delta T Cells
  • Glucose Homeostasis
  • Helper T (Th) Cells
  • HIF Transcription Factors
  • ICC / IHC Images: IL-6
  • IL-6 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Interactive Pathway: Adipocytokines & Insulin Signaling
  • Interactive Pathway: Th17 Differentiation
  • Macrophage Activation Markers
  • Mini-review: Interleukin 6
  • Mouse Obesity Antibody Array
  • Multiple Myeloma
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • Role of IL-6 in Energy Expenditure
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th22 Cells
  • Th9 Cells