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Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit (1 KT)

货号: MOP00 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号MOP00
描述The Quantikine Mouse OPG Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse OPG in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse OPG and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse OPG accurately. Results obtained using natural mouse OPG showed dose response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse OPG.
别名OCIF; OCIFMGC29565; OPGtumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily, member 11b;
反应种属Mouse
目标/特异性Natural and recombinant mouse OPG
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
4982 (Human); 18383 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Silicon Nitride: A Synthetic Mineral for Vertebrate Biology
Sci Rep, 2016;6(0):31717.
Species: Human
Sample Type: Cell Culture Supernates

Deletion of FoxO1, 3 and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes
J Bone Miner Res, 2016;0(0):.
Species: Mouse
Sample Type: Plasma

Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts.
Authors: Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U
J Biol Chem, 2015;290(33):20147-58.
Species: Mouse
Sample Type: Tissue Homogenates

Effects of neuropeptides and mechanical loading on bone cell resorption in vitro.
Authors: Yoo Y, Kwag J, Kim K, Kim C
Int J Mol Sci, 2014;15(4):5874-83.
Species: Mouse
Sample Type: cell supernates

Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.
Authors: Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, Van Dyke T, Gyurko R
J Immunol, 2013;190(2):689-94.
Species: Mouse
Sample Type: cell culture supernate

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5).
Authors: Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
J Bone Miner Res, 2013;28(10):2070-80.
Species: Mouse
Sample Type: Cell Culture Supernates

Osteoprotection by semaphorin 3A.
Authors: Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H
Nature, 2012;485(7396):69-74.
Species: Mouse
Sample Type: Serum

Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway.
Authors: Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ
Acta Pharmacol. Sin., 2012;33(4):479-89.
Species: Rat
Sample Type: Serum

The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice.
Authors: Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, OBrien CA
Mol. Endocrinol., 2012;26(2):341-8.
Species: Mouse
Sample Type: Plasma

Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma.
Authors: Buckle, Clive He, De Leenheer, Evy, Lawson, Michelle, Yong, Kwee, Rabin, Neil, Perry, Mark, Vanderkerken, Karen, Croucher, Peter Ia
PLoS ONE, 2012;7(8):e41127.
Species: Mouse
Sample Type: Serum

Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis.
Authors: Ho TY, Santora K, Chen JC, Frankshun AL, Bagnell CA
Bone, 2011;48(6):1346-53.
Species: Rat
Sample Type: Plasma

Systemic effects of ulna loading in male rats during functional adaptation.
Authors: Sample SJ, Collins RJ, Wilson AP, Racette MA, Behan M, Markel MD, Kalscheur VL, Hao Z, Muir P
J. Bone Miner. Res., 2010;25(9):2016-28.
Species: Rat
Sample Type: Plasma

Increased trabecular bone formation in mice lacking the growth factor midkine.
Authors: Neunaber C, Catala-Lehnen P, Beil FT
J. Bone Miner. Res., 2010;25(8):1724-35.
Species: Mouse
Sample Type: Serum

Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome.
Authors: OConnor RD, Zayzafoon M, Farach-Carson MC, Schanen NC
Bone, 2009;45(2):346-56.
Species: Mouse
Sample Type: Serum

ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Authors: Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A
Blood, 2009;114(15):3216-26.
Species: Mouse
Sample Type: Serum

Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
Authors: Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL
J. Bone Miner. Res., 2009;24(5):775-84.
Species: Mouse
Sample Type: Cell Culture Supernates

Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.
Authors: Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL
Circulation, 2008;117(3):411-20.
Species: Mouse
Sample Type: Plasma

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.
Authors: Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD
Blood, 2008;112(1):196-207.
Species: Mouse
Sample Type: Cell Culture Supernates

B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo.
Authors: Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian WP, Weitzmann MN
Blood, 2007;109(9):3839-48.
Species: Mouse
Sample Type: Cell Culture Supernates

Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts.
Authors: Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, Mizoguchi T, Sato M, Mogi M, Penninger JM, Takahashi N
J. Immunol., 2007;178(1):192-200.
Species: Mouse
Sample Type: Serum

EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases.
Authors: Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L
J. Biol. Chem., 2007;282(37):26656-64.
Species: Mouse
Sample Type: Cell Culture Supernates

Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells.
Authors: Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G
Blood, 2007;111(3):1287-94.
Species: Mouse
Sample Type: Serum

JunB as a downstream mediator of PTHrP actions in cementoblasts.
Authors: Berry JE, Ealba EL, Pettway GJ, Datta NS, Swanson EC, Somerman MJ, McCauley LK
J. Bone Miner. Res., 2005;21(2):246-57.
Species: Mouse
Sample Type: Cell Culture Supernates

Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule.
Authors: Zehnder AF, Kristiansen AG, Adams JC, Merchant SN, McKenna MJ
Laryngoscope, 2005;115(1):172-7.
Species: Mouse
Sample Type: Serum

IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.
Authors: Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, Kolls JK, Joosten LA, van den Berg WB
J. Immunol., 2003;170(5):2655-62.
Species: Mouse
Sample Type: Synovial Fluid

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.
运输条件Blue Ice
存放说明4℃
参考文献
  • Gametes and Fertilization
  • Glucose Homeostasis
  • ICC / IHC Images: Osteoprotegerin/TNFRSF11B
  • Regulation of Apoptosis by TNF Superfamily Members
  • TNF Superfamily
  • TNF Superfamily Receptors