| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli.
Authors: Bramwell K, Mock K, Ma Y, Weis J, Teuscher C, Weis J
J Immunol, 2015;195(4):1647-56.
Species: Mouse
Sample Type: Cell Culture Supernates
SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.
Authors: Iyer S, Brooks R, Gumbleton M, Kerr W
Stem Cells Dev, 2015;24(9):1073-81.
Species: Mouse
Sample Type: Serum
Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.
Authors: Brouxhon, S M, Kyrkanides, S, Teng, X, Athar, M, Ghazizadeh, S, Simon, M, OBanion, M K, Ma, L
Oncogene, 2014;33(2):225-35.
Species: Mouse
Sample Type: Cell Culture Supernates
Notch-1 mediated cardiac protection following embryonic and induced pluripotent stem cell transplantation in doxorubicin-induced heart failure.
Authors: Merino H, Singla D
PLoS ONE, 2014;9(7):e101024.
Species: Mouse
Sample Type: Tissue Homogenates
Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer.
Authors: Bakalova R, Zhelev Z, Aoki I, Saga T
Clin Cancer Res, 2013;19(9):2503-17.
Species: Mouse
Sample Type: Plasma
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
Authors: Tran, Kim, Risingsong, Renee, Royce, Darlene, Williams, Charlott, Sporn, Michael, Pioli, Patricia, Gediya, Lalji K, Njar, Vincent, Liby, Karen T
Carcinogenesis, 2013;34(1):199-210.
Species: Mouse
Sample Type: cell supernates
A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.
Eur J Immunol, 2012;42(9):2395-408.
Species: Mouse
Sample Type: BALF
Role of c-Jun N-terminal protein kinase 1/2 (JNK1/2) in macrophage-mediated MMP-9 production in response to Moraxella catarrhalis lipooligosaccharide (LOS).
Authors: Hassan F, Ren D, Zhang W
PLoS ONE, 2012;7(5):e37912.
Species: Mouse
Sample Type: Cell Culture Supernates
The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
Authors: Tran K, Risingsong R, Royce D
Cancer Prev Res (Phila), 2012;5(5):726-34.
Species: Mouse
Sample Type: Cell Culture Supernates
The effects of low levels of dystrophin on mouse muscle function and pathology.
Authors: van Putten M, Hulsker M, Nadarajah VD, van Heiningen SH, van Huizen E, van Iterson M, Admiraal P, Messemaker T, den Dunnen JT, t Hoen PA, Aartsma-Rus A
PLoS ONE, 2012;7(2):e31937.
Species: Mouse
Sample Type: Serum
Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5.
Authors: Conant K, Lonskaya I, Szklarczyk A, Krall C, Steiner J, Maguire-Zeiss K, Lim ST
J. Neurochem., 2011;118(4):521-32.
Species: Mouse
Sample Type: Cell Lysates
Activation of matrix metalloproteinases following anti-Abeta immunotherapy; implications for microhemorrhage occurrence.
Authors: Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA
J Neuroinflammation, 2011;8(0):115.
Species: Mouse
Sample Type: Tissue Homogenates
Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.
Authors: Liu ZB, Hou YF, Zhu J
Oncogene, 2010;29(20):2996-3009.
Species: Mouse
Sample Type: Serum
Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
Neurobiol. Dis., 2010;38(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates
Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene.
Authors: Sio SW, Moochhala S, Lu J
Am. J. Respir. Crit. Care Med., 2010;181(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates
15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model.
Authors: Chen QH, Zhou WD, Pu DM, Huang QS, Li T, Chen QX
Fertil. Steril., 2010;93(5):1440-7.
Species: Mouse
Sample Type: Peritoneal Fluid
Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
J. Neurochem., 2009;111(6):1409-24.
Species: Mouse
Sample Type: Tissue Homogenates
Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.
Authors: Hamada T, Duarte S, Tsuchihashi S, Busuttil RW, Coito AJ
Am. J. Pathol., 2009;174(6):2265-77.
Species: Mouse
Sample Type: Cell Culture Supernates
Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain.
Authors: Wang P, Dai J, Bai F, Kong KF, Wong SJ, Montgomery RR, Madri JA, Fikrig E
J. Virol., 2008;82(18):8978-85.
Species: Mouse
Sample Type: Serum
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| 背景 | The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP). |
