Mouse/Rat FGF-21 Quantikine ELISA Kit (1 KT)【科瑞奥博】

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Mouse/Rat FGF-21 Quantikine ELISA Kit (1 KT)

货号： MF2100 基本售价： 6791.4 元规格： 1 Kit

产品信息

概述
货号	MF2100
描述	The Quantikine Mouse/Rat FGF-21 immunoassay is a 4.5 hour solid-phase ELISA designed to measure FGF-21 in mouse or rat cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse FGF-21 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse FGF-21. Results obtained using natural mouse or rat FGF-21 showed dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural FGF-21.
别名	FGF-21; fibroblast growth factor 21;
全称	Fibroblast Growth Factor 21
反应种属	Mouse/Rat
目标/特异性	Natural and recombinant mouse and rat FGF-21

性能
供应商	R&D Systems
检测类型	Solid Phase Sandwich ELISA
Entrez Gene IDs	26291 (Human); 56636 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system Authors: Yoshimi Nakagawa Sci Rep, 2016;6(0):27857. Species: Mouse Sample Type: Plasma Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects Authors: Tsutomu Hashidume Sci Rep, 2016;6(0):28183. Species: Mouse Sample Type: Serum CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis Authors: Jong-Gil Park Sci Rep, 2016;6(0):27938. Species: Mouse Sample Type: Plasma The Orphan Nuclear Receptor ERR? Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression PLoS ONE, 2016;11(7):e0159425. Species: Mouse Sample Type: Serum Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction Authors: Jong-Ho Kim PLoS ONE, 2016;11(6):e0158067. Species: Mouse Sample Type: Cell Culture Supernates A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Authors: Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S, Tanaka H Nat Commun, 2015;6(0):6693. Species: Mouse Sample Type: Plasma Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Authors: Lawan A, Zhang L, Gatzke F, Min K, Jurczak M, Al-Mutairi M, Richter P, Camporez J, Couvillon A, Pesta D, Roth Flach R, Shulman G, Bennett A Mol Cell Biol, 2015;35(1):26-40. Species: Mouse Sample Type: Serum Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Authors: Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst E, Keijer J, Klaus S Am J Physiol Endocrinol Metab, 2014;306(5):E469-82. Species: Mouse Sample Type: Plasma Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice. Authors: Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H PLoS ONE, 2014;9(8):e104948. Species: Mouse Sample Type: Serum Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Authors: Ahlqvist KJ, Hamalainen RH, Yatsuga S, Uutela M, Terzioglu M, Gotz A, Forsstrom S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A Cell Metab., 2012;15(1):100-9. Species: Mouse Sample Type: Serum Activation of the farnesoid x receptor induces hepatic expression and secretion of fibroblast growth factor 21. Authors: Cyphert HA, Ge X, Kohan AB, Salati LM, Zhang Y, Hillgartner FB J. Biol. Chem., 2012;287(30):25123-38. Species: Rat Sample Type: Plasma Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice. Authors: Archer A, Venteclef N, Mode A, Pedrelli M, Gabbi C, Clement K, Parini P, Gustafsson J, Korach-Andre M Mol Endocrinol, 2012;26(12):1980-90. Species: Mouse Sample Type: Serum Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? Authors: Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E PLoS ONE, 2011;6(8):e22976. Species: Human Sample Type: Cell Culture Supernates
生物活性	< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景	FGF-21 (Fibroblast Growth Factor 21) is a member of an FGF subfamily that also includes FGF-19 and FGF-23. FGF-19 subfamily members lack a heparin binding domain, enabling them to freely circulate as endocrine factors and diffuse within tissues. FGF-21 signals through Klotho beta in complex with FGF receptors. It regulates cellular metabolism including glucose uptake in adipocytes and cellular sensitivity to insulin. It is basally expressed in the pancreas, thymus, liver, and adipose tissue and is upregulated in liver, muscle, and fat in obesity and diabetes. FGF-21 also plays a role in cell survival and proliferation, mesenchymal stem cell differentiation, circadian rhythm, and controlling reproductive capacity.
运输条件	Blue Ice
存放说明	4℃
参考文献	Diabetes FGF Family FGF Ligands FGF-21: From Cloning to Clinic Glucose Homeostasis Mini-review: Fibroblast Growth Factors (FGFs) Obesity