Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity
Authors: G Hoppe, S Yoon, B Gopalan, AR Savage, R Brown, K Case, A Vasanji, ER Chan, RB Silver, JE Sears
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: Serum

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
Nat Commun, 2016;7(0):12177.
Species: Mouse
Sample Type: Peritoneal Fluid

Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis
Authors: T Kamio, BW Gu, TS Olson, Y Zhang, PJ Mason, M Bessler
PLoS ONE, 2016;11(4):e0152263.
Species: Mouse
Sample Type: Serum

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Authors: Canli O, Alankus Y, Grootjans S, Vegi N, Hultner L, Hoppe P, Schroeder T, Vandenabeele P, Bornkamm G, Greten F
Blood, 2016;127(1):139-48.
Species: Mouse
Sample Type: Serum

Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia
Authors: AC Selfridge, MA Cavadas, CC Scholz, EL Campbell, LC Welch, E Lecuona, SP Colgan, KE Barrett, PH Sporn, JI Sznajder, EP Cummins, CT Taylor
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Type: Serum

Salmonella infection enhances erythropoietin production by the kidney and liver correlating with elevated bacterial burdens
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Serum

The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 is Essential for Efficient Hydroxylation of Hypoxia Inducible Factor-?
Authors: Patrick R Arsenault
Mol Cell Biol, 2016;0(0):.
Species: Mouse
Sample Type: Serum

The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia
Authors: RB Hamanaka, SE Weinberg, CR Reczek, NS Chandel
Cell Rep, 2016;15(3):451-9.
Species: Mouse
Sample Type: Serum

An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin.
Authors: Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, Raymon H, Heise C, Daniel T, Chopra R, Sung V
Br J Haematol, 2014;165(6):870-82.
Species: Mouse
Sample Type: Plasma

Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates.
Authors: Le Guiner C, Stieger K, Toromanoff A, Guilbaud M, Mendes-Madeira A, Devaux M, Guigand L, Cherel Y, Moullier P, Rolling F, Adjali O
PLoS ONE, 2014;9(9):e102538.
Species: Mouse
Sample Type: Serum

Inducing a visceral organ to protect a peripheral capillary bed: stabilizing hepatic HIF-1alpha prevents oxygen-induced retinopathy.
Authors: Hoppe G, Lee T, Yoon S, Yu M, Peachey N, Rayborn M, Zutel M, Trichonas G, Au J, Sears J
Am J Pathol, 2014;184(6):1890-9.
Species: Mouse
Sample Type: Serum

Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis.
Authors: Vadakke Madathil S, Coe L, Casu C, Sitara D
Am J Pathol, 2014;184(3):827-41.
Species: Mouse
Sample Type: Serum

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.
Authors: Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U
PLoS ONE, 2014;9(11):e111838.
Species: Rat
Sample Type: Plasma

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.
Authors: Arsenault, Patrick, Pei, Fei, Lee, Rebecca, Kerestes, Heddy, Percy, Melanie, Keith, Brian, Simon, M Celest, Lappin, Terence, Khurana, Tejvir S, Lee, Frank S
J Biol Chem, 2013;288(47):33571-84.
Species: Mouse
Sample Type: Serum

Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea.
BMC Neurosci, 2012;13(0):77.
Species: Mouse
Sample Type: Tissue Homogenates

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.
Authors: Querbes, William, Bogorad, Roman L, Moslehi, Javid, Wong, Jamie, Chan, Amy Y, Bulgakova, Elena, Kuchimanchi, Satya, Akinc, Akin, Fitzgerald, Kevin, Koteliansky, Victor, Kaelin, William
Blood, 2012;120(9):1916-22.
Species: Mouse
Sample Type: Serum

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.
Authors: Peslak, Scott A, Wenger, Jesse, Bemis, Jeffrey, Kingsley, Paul D, Koniski, Anne D, McGrath, Kathleen, Palis, James
Blood, 2012;120(12):2501-11.
Species: Mouse
Sample Type: Plasma

Minimal doses of a sequence-optimized transgene mediate high-level and long-term EPO expression in vivo: challenging CpG-free gene design.
Authors: Kosovac D, Wild J, Ludwig C, Meissner S, Bauer AP, Wagner R
Gene Ther., 2011;18(2):189-98.
Species: Mouse
Sample Type: Serum

A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.
Authors: Salojin KV, Cabrera RM, Sun W
Blood, 2011;117(18):4895-904.
Species: Mouse
Sample Type: Serum

Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling.
Authors: Talbot AL, Bullock GC, Delehanty LL
PLoS ONE, 2011;6(8):e23850.
Species: Mouse
Sample Type: Serum

General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain.
Authors: Tanaka T, Kai S, Koyama T, Daijo H, Adachi T, Fukuda K, Hirota K
PLoS ONE, 2011;6(12):e29378.
Species: Mouse
Sample Type: Tissue Homogenates

A postweaning iron-adequate diet following neonatal iron deficiency affects iron homeostasis and growth in young rats.
Authors: Hegde NV, Jensen GL, Unger EL
J. Nutr., 2011;141(3):386-90.
Species: Rat
Sample Type: Serum

3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.
Authors: Ikeda K, Mason PJ, Bessler M
Blood, 2011;117(22):5860-9.
Species: Mouse
Sample Type: Serum

Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6.
Authors: Ramadori P, Ahmad G, Ramadori G
Lab. Invest., 2010;90(9):1306-24.
Species: Mouse
Sample Type: Serum

Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice.
Authors: Gothelf A, Hojman P, Gehl J
Gene Ther., 2010;17(9):1077-84.
Species: Mouse
Sample Type: Serum

Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly.
Authors: Jackson A, Nanton MR, ODonnell H
J. Immunol., 2010;185(10):6198-204.
Species: Mouse
Sample Type: Serum

AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress.
Authors: Wang S, Dale GL, Song P
J. Biol. Chem., 2010;285(26):19976-85.
Species: Mouse
Sample Type: Plasma

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.
Authors: Li J, Spensberger D, Ahn JS
Blood, 2010;116(9):1528-38.
Species: Mouse
Sample Type: Plasma

Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection.
Authors: Morrison LJ, McLellan S, Sweeney L, Chan CN, MacLeod A, Tait A, Turner CM
Infect. Immun., 2010;78(3):1096-108.
Species: Mouse
Sample Type: Plasma

Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.
Authors: Schneider C, Krischke G, Keller S, Walkinshaw G, Arend M, Rascher W, Gassmann M, Trollmann R
Brain Res., 2009;1280(0):43-51.
Species: Mouse
Sample Type: Serum

Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
Authors: Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(6):L1160-9.
Species: Mouse
Sample Type: Serum

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.
Authors: Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS
J. Clin. Invest., 2009;119(11):3373-83.
Species: Mouse
Sample Type: Plasma

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.
Authors: Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C
J. Clin. Invest., 2009;119(5):1159-66.
Species: Mouse
Sample Type: Serum

Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme.
Authors: Meza NW, Alonso-Ferrero ME, Navarro S, Quintana-Bustamante O, Valeri A, Garcia-Gomez M, Bueren JA, Bautista JM, Segovia JC
Mol. Ther., 2009;17(12):2000-9.
Species: Mouse
Sample Type: Plasma

Epidermal sensing of oxygen is essential for systemic hypoxic response.
Authors: Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS
Cell, 2008;133(2):223-34.
Species: Mouse
Sample Type: Plasma

n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems.
Authors: Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K
Biochem. J., 2008;411(1):97-105.
Species: Mouse
Sample Type: Serum

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.
Authors: Xing S, Wanting TH, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ
Blood, 2008;111(10):5109-17.
Species: Mouse
Sample Type: Plasma

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
Authors: Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW
Blood, 2008;112(9):3878-88.
Species: Mouse
Sample Type: Serum

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.
Authors: Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC
Blood, 2007;111(8):3931-40.
Species: Mouse
Sample Type: Plasma

Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability.
Authors: Geny B, Khun H, Fitting C, Zarantonelli L, Mazuet C, Cayet N, Szatanik M, Prevost MC, Cavaillon JM, Huerre M, Popoff MR
Am. J. Pathol., 2007;170(3):1003-17.
Species: Mouse
Sample Type: Tissue Homogenates

Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
Authors: Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW
Exp. Cell Res., 2007;313(20):4120-9.
Species: Mouse
Sample Type: Serum

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
Authors: Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC
J. Clin. Invest., 2007;117(12):3879-3889.
Species: Mouse
Sample Type: Serum

Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy.
Authors: Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS
Proc. Natl. Acad. Sci. U.S.A., 2007;104(43):17069-74.
Species: Mouse
Sample Type: Plasma

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
Blood, 2006;108(6):2041-4.
Species: Mouse
Sample Type: Serum

Suppression of hepcidin during anemia requires erythropoietic activity.
Authors: Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S
Blood, 2006;108(12):3730-5.
Species: Mouse
Sample Type: Serum

The biological effects of Epo are mediated by the Erythropoietin receptor (Epo R). At the protein sequence level, the human Epo R is approximately 83% identical to the mouse protein. As a result of alternative splicing of the Epo R gene, cDNA clones encoding truncated soluble forms of Epo R have been found. Recombinant soluble Epo R binds Epo with high affinity and is a potent Epo antagonist.

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