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Mouse G-CSF Quantikine ELISA Kit (1 KT)

货号: MCS00 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号MCS00
描述The Quantikine Mouse G-CSF Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse G-CSF in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse G-CSF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse G-CSF accurately. Results obtained using natural mouse G-CSF showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse G-CSF.
别名C17orf33; chromosome 17 open reading frame 33; colony stimulating factor 3 (granulocyte); CSF3; CSF3OS; Filgrastim; G-CSF; GCSFlenograstim; granulocyte colony-stimulating factor; Lenograstim; MGC45931; pluripoietin;
全称
Granulocyte Colony Stimulating Factor
反应种属Mouse
目标/特异性Natural and recombinant mouse G-CSF
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
1440 (Human); 12985 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3' untranslated region in macrophages independently of its effect on p38 MAPK activity.
Authors: Chang S, Li H, Huang Y, Tasi W, Chou Y, Lu S
J Biomed Sci, 2016;23(1):3.
Species: Mouse
Sample Type: Cell Culture Supernates

Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells
Authors: A Spiegel, MW Brooks, S Houshyar, F Reinhardt, M Ardolino, E Fessler, MB Chen, JA Krall, J DeCock, IK Zervantona, A Iannello, Y Iwamoto, V Cortez-Ret, RD Kamm, MJ Pittet, DH Raulet, RA Weinberg
Cancer Discov, 2016;0(0):.
Species: Mouse
Sample Type: Plasma

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Cell, 2016;0(0):.
Species: Mouse
Sample Type: Serum

Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
Stem Cell Reports, 2016;0(0):.
Species: Mouse
Sample Type: Serum

SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.
Authors: Iyer S, Brooks R, Gumbleton M, Kerr W
Stem Cells Dev, 2015;24(9):1073-81.
Species: Mouse
Sample Type: Serum

gammadelta T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice.
Authors: Mathews J, Kasahara D, Ribeiro L, Wurmbrand A, Ninin F, Shore S
PLoS ONE, 2015;10(7):e0131236.
Species: Mouse
Sample Type: BALF

Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi.
Authors: Brooks R, Iyer S, Akada H, Neelam S, Russo C, Chisholm J, Kerr W
Stem Cells, 2015;33(3):848-58.
Species: Mouse
Sample Type: Serum

Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Authors: Jiao, Jingjing, Dragomir, Ana-Cris, Kocabayoglu, Peri, Rahman, Adeeb H, Chow, Andrew, Hashimoto, Daigo, Leboeuf, Marylene, Kraus, Thomas, Moran, Thomas, Carrasco-Avino, Gonzalo, Friedman, Scott L, Merad, Miriam, Aloman, Costica
J Immunol, 2014;192(7):3374-82.
Species: Mouse
Sample Type: Plasma

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
Authors: Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M
Blood, 2014;124(9):1393-403.

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
Authors: Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H
Blood, 2013;121(5):723-33.
Species: Mouse
Sample Type: Plasma

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita.
Authors: Beier, Fabian, Foronda, Miguel, Martinez, Paula, Blasco, Maria A
Blood, 2012;120(15):2990-3000.
Species: Mouse
Sample Type: Serum

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
Authors: Kreisel D, Sugimoto S, Tietjens J, Zhu J, Yamamoto S, Krupnick AS, Carmody RJ, Gelman AE
J. Clin. Invest., 2011;121(1):265-76.
Species: Mouse
Sample Type: Serum

Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism.
Authors: Waight JD, Hu Q, Miller A, Liu S, Abrams SI
PLoS ONE, 2011;6(11):e27690.
Species: Mouse
Sample Type: Cell Culture Supernates

Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Authors: Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI
J. Immunol., 2011;186(5):2826-34.
Species: Mouse
Sample Type: Plasma

Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.
Authors: McDermott DH, De Ravin SS, Jun HS
Blood, 2010;116(15):2793-802.
Species: Mouse
Sample Type: Serum

Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
Authors: Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS
Cancer Cell, 2008;14(3):263-73.
Species: Mouse
Sample Type: Plasma

The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts.
Authors: Gomez JC, Soltys J, Okano K, Dinauer MC, Doerschuk CM
Am. J. Pathol., 2008;173(2):507-17.
Species: Mouse
Sample Type: Plasma

Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy.
Authors: Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS
Proc. Natl. Acad. Sci. U.S.A., 2007;104(43):17069-74.
Species: Mouse
Sample Type: Plasma

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
Authors: Gregory AD, Hogue LA, Ferkol TW, Link DC
Blood, 2007;109(8):3235-43.
Species: Mouse
Sample Type: epithelial lining fluid

Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions.
Authors: Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY
J. Biol. Chem., 2006;281(39):28794-801.
Species: Mouse
Sample Type: Plasma

Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.
Authors: Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ
J. Mol. Cell. Cardiol., 2006;41(1):34-43.
Species: Mouse
Sample Type: Plasma

A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
Authors: Liao HF, Chen YJ, Yang YC
Life Sci., 2005;77(4):400-13.
Species: Mouse
Sample Type: Cell Culture Supernates

Modulation of marrow proliferation and chemosensitivity by tumor-produced cytokines from syngeneic pancreatic tumor lines.
Authors: Blumenthal RD, Reising A, Leon E
Clin. Cancer Res., 2002;8(5):1301-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Granulocyte colony-stimulating factor: release is not impaired after burn wound infection.
Authors: Gamelli R, He LK, Hahn E
J Trauma, 2002;53(2):284-9; discus.
Species: Mouse
Sample Type: Serum

The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Arch. Dermatol. Res., 2001;293(10):508-14.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景G-CSF (granulocyte-colony stimulating factor) is a secreted glycoprotein that regulates the proliferation, differentiation, and activation of neutrophilic granulocyte lineage cells. It also enhances M-CSF induced monocyte differentiation and the proliferation of Th2-inducing dendritic cells. G-CSF promotes the development of T cell immune tolerance as well as tissue recovery following myocardial infarction and cerebral ischemia. It signals through G-CSF R/CD114 on monocytes, neutrophils, megakaryocytes, platelets, myeloid progenitors, trophoblasts and placenta, endothelial cells, and various tumor cell types. Mutations in G-CSF R are associated with congenital neutropenia.
运输条件Blue Ice
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参考文献
  • A novel role for the nervous system in HSPS mobilization
  • ALS Related Molecules
  • Cytokines and Receptors in Angiogenesis
  • Gametes and Fertilization
  • IL-6 Family
  • Macrophage Activation Markers