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Mouse CCL17/TARC Quantikine ELISA Kit (1 KT)

货号: MCC170 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号MCC170
描述The Quantikine Mouse TARC Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TARC levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse TARC and antibodies raised against the recombinant factor. Results obtained for naturally occurring mouse TARC showed linear curves that were parallel to the standard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TARC.
别名ABCD-2; CC chemokine TARC; C-C motif chemokine 17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARC; TARCA-152E5.3; Thymus and activation-regulated chemokine;
反应种属Mouse
目标/特异性Natural and recombinant mouse TARC
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6361 (Human); 20295 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
Authors: Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H
Nat Commun, 2015;6(0):6224.
Species: Mouse
Sample Type: BALF

Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
Authors: Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan D, Kong H, Amagai M, Nagao K
Immunity, 2015;42(4):756-66.
Species: Mouse
Sample Type: Serum

Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy.
Authors: Brenndorfer E, Brass A, Karthe J, Ahlen G, Bode J, Sallberg M
J Immunol, 2014;192(4):1671-80.
Species: Mouse
Sample Type: Cell Extracts

Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration.
Authors: Maina, Virginia, Marrella, Veronica, Mantero, Stefano, Cassani, Barbara, Fontana, Elena, Anselmo, Achille, Del Prete, Annalisa, Sozzani, Silvano, Vezzoni, Paolo, Poliani, Pietro L, Villa, Anna
J Leukoc Biol, 2013;94(6):1221-30.
Species: Mouse
Sample Type: Tissue Homogenates

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.
J. Immunol., 2012;189(5):2545-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Authors: Olkhanud PB, Rochman Y, Bodogai M
J. Immunol., 2011;186(10):5656-62.
Species: Mouse
Sample Type: Plasma

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease.
Authors: Taube C, Tertilt C, Gyulveszi G, Dehzad N, Kreymborg K, Schneeweiss K, Michel E, Reuter S, Renauld JC, Arnold-Schild D, Schild H, Buhl R, Becher B
PLoS ONE, 2011;6(7):e21799.
Species: Mouse
Sample Type: BALF

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
Clin. Exp. Allergy, 2011;41(10):1447-55.
Species: Mouse
Sample Type: BALF

IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Authors: Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C
J. Immunol., 2011;186(4):2372-81.
Species: Mouse
Sample Type: Tissue Homogenates

Thymic stromal lymphopoietin is produced by dendritic cells.
Authors: Kashyap M, Rochman Y, Spolski R
J. Immunol., 2011;187(3):1207-11.
Species: Mouse
Sample Type: BALF

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Authors: Louten J, Rankin AL, Li Y
Int. Immunol., 2011;23(5):307-15.
Species: Mouse
Sample Type: BALF

Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.
Authors: Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM
J. Allergy Clin. Immunol., 2010;125(1):160-9.e1-5.
Species: Mouse
Sample Type: Serum

Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
Authors: Chen G, Wan H, Luo F
J. Immunol., 2010;184(11):6133-41.
Species: Mouse
Sample Type: BALF

Disruption of interleukin-1 signaling improves the quality of wound healing.
Authors: Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE
Am. J. Pathol., 2009;174(6):2129-36.
Species: Mouse
Sample Type: wound fluid

CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
Authors: Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD
J. Immunol., 2009;182(1):623-35.
Species: Mouse
Sample Type: BALF

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.
Authors: Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM
J. Invest. Dermatol., 2009;129(7):1824-35.
Species: Mouse
Sample Type: Serum

Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.
Authors: Chiba Y, Sato S, Misawa M
Inflamm. Res., 2009;0(0):.
Species: Mouse
Sample Type: BALF

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.
Authors: Voskas D, Babichev Y, Ling LS, Alami J, Shaked Y, Kerbel RS, Ciruna B, Dumont DJ
J. Leukoc. Biol., 2008;84(1):59-67.
Species: Mouse
Sample Type: Serum

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
J. Exp. Med., 2008;205(3):699-710.
Species: Mouse
Sample Type: BALF

A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
Authors: Trujillo G, OConnor EC, Kunkel SL, Hogaboam CM
Am. J. Pathol., 2008;172(5):1209-21.
Species: Mouse
Sample Type: Tissue Homogenates

Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.
Authors: Zhou W, Newcomb DC, Moore ML, Goleniewska K, ONeal JF, Peebles RS
J. Immunol., 2008;181(8):5360-7.
Species: Mouse
Sample Type: Tissue Homogenates

The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
Authors: Fujita H, Asahina A, Komine M, Tamaki K
Cell. Immunol., 2007;245(2):70-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Prolonged inhaled allergen exposure can induce persistent tolerance.
Authors: Van Hove CL, Maes T, Joos GF, Tournoy KG
Am. J. Respir. Cell Mol. Biol., 2007;36(5):573-84.
Species: Mouse
Sample Type: Cell Culture Supernates

iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.
Authors: Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT
J. Immunol., 2007;179(7):4661-71.
Species: Mouse
Sample Type: Tissue Homogenates

Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.
Authors: Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR
J. Immunol., 2007;178(10):6191-9.
Species: Mouse
Sample Type: BALF

Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
Authors: Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
Am. J. Pathol., 2007;170(4):1152-64.
Species: Mouse
Sample Type: Tissue Homogenates

Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis.
Authors: Drmotova M, Rehnstrom E, Jansson L
Cytokine, 2006;35(5):275-83.
Species: Mouse
Sample Type: Tissue Homogenates

CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli.
Authors: Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K
Eur. J. Immunol., 2006;36(8):2116-27.
Species: Mouse
Sample Type: Serum

Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Authors: Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X
Biochem. Biophys. Res. Commun., 2006;345(3):1122-30.
Species: Mouse
Sample Type: Cell Culture Supernates

Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues.
Authors: Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M
J. Immunol., 2006;176(4):2568-80.
Species: Mouse
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CCL17/TARC is a chemokine that interacts with CCR4 and CCR8 to induce the chemoattraction of activated Th2 cells, basophils, and NK cells. It is produced by thymic dendritic cells, lymph node dendritic cells, monocytes, CD4+ T cells, keratinocytes, fibroblasts, bronchial epithelial cells, and Reed-Sternberg cells. CCL17 promotes Th2 cell recruitment to sites of inflammation and induces platelet aggregation and degranulation.
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参考文献
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Macrophage Activation Markers
  • Regulatory T Cells (Tregs)
  • Th9 Cells