Exosomes in Human Breast Milk Promote EMT
Authors: W Qin, Y Tsukasaki, S Dasgupta, N Mukhopadhy, M Ikebe, ER Sauter
Clin Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Cell Lysates

Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
Authors: Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P
PLoS ONE, 2015;10(5):e0124865.
Species: Human
Sample Type: Cell Culture Supernates

Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model.
Authors: Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D
J Transl Med, 2014;12(1):330.
Species: Human
Sample Type: Serum

Validation and quality control of ELISAs for the use with human saliva samples.
Authors: Jaedicke KM, Taylor JJ, Preshaw PM
J. Immunol. Methods, 2012;377(1):62-5.
Species: Human
Sample Type: Saliva

Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade.
Authors: Symeonidis C, Papakonstantinou E, Androudi S, Tsaousis KT, Tsinopoulos I, Brazitikos P, Karakiulakis G, Diza E, Dimitrakos SA
Cytokine, 2012;59(1):184-90.
Species: Human
Sample Type: Subretinal fluid

Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy.
Authors: Symeonidis C, Papakonstantinou E, Androudi S, Rotsos T, Diza E, Brazitikos P, Karakiulakis G, Dimitrakos SA
Cytokine, 2011;54(2):212-7.
Species: Human
Sample Type: Vitreous Humor

Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
Authors: Yamakawa N, Uchida T, Matthay MA, Makita K
Am. J. Physiol. Lung Cell Mol. Physiol., 2011;300(4):L516-25.
Species: Human
Sample Type: pulmonary edema fluid

Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Authors: Verma S, Kumar M, Nerurkar VR
J. Gen. Virol., 2011;92(0):507-15.
Species: Human
Sample Type: Cell Culture Supernates

Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival.
Authors: Yeh YC, Sheu BS, Cheng HC, Wang YL, Yang HB, Wu JJ
Dig. Dis. Sci., 2010;55(6):1649-57.
Species: Human
Sample Type: Serum

Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure.
Authors: Buralli S, Dini FL, Ballo P, Conti U, Fontanive P, Duranti E, Metelli MR, Marzilli M, Taddei S
Am. J. Cardiol., 2010;105(6):853-6.
Species: Human
Sample Type: Plasma

Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study.
Authors: Kawut SM, Barr RG, Johnson WC
Biomarkers, 2010;15(8):731-8.
Species: Human
Sample Type: Plasma

Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
Eur. J. Haematol., 2010;84(3):239-51.
Species: Human
Sample Type: Cell Culture Supernates

Soluble biomarkers of cartilage and bone metabolism in early proof of concept trials in psoriatic arthritis: effects of adalimumab versus placebo.
Authors: van Kuijk AW, DeGroot J, Koeman RC
PLoS ONE, 2010;5(9):e12556.
Species: Human
Sample Type: Serum

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1.
Authors: Hashizume M, Mihara M
Biochem. Biophys. Res. Commun., 2010;403(2):184-9.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia.
Authors: Karapanagiotidis GT, Antonitsis P, Charokopos N, Foroulis CN, Anastasiadis K, Rouska E, Argiriadou H, Rammos K, Papakonstantinou C
J Cardiothorac Surg, 2009;4(0):59.
Species: Human
Sample Type: Serum

Establishment of a matrix-associated transepithelial resistance invasion assay to precisely measure the invasive potential of synovial fibroblasts.
Authors: Wunrau C, Schnaeker EM, Freyth K, Pundt N, Wendholt D, Neugebauer K, Hansen U, Pap T, Dankbar B
Arthritis Rheum., 2009;60(9):2606-11.
Species: Human
Sample Type: Cell Culture Supernates

PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis.
Authors: Hayer S, Pundt N, Peters MA, Wunrau C, Kuhnel I, Neugebauer K, Strietholt S, Zwerina J, Korb A, Penninger J, Joosten LA, Gay S, Ruckle T, Schett G, Pap T
FASEB J., 2009;23(12):4288-98.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of IL-1beta-mediated inflammatory responses by the IkappaB alpha super-repressor in human fibroblast-like synoviocytes.
Authors: Lee YR, Kweon SH, Kwon KB, Park JW, Yoon TR, Park BH
Biochem. Biophys. Res. Commun., 2009;378(1):90-4.
Species: Human
Sample Type: Cell Culture Supernates

Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.
Authors: Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P
Atherosclerosis, 2009;202(2):550-6.
Species: Human
Sample Type: Serum

Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Authors: Agarwal A, Covic L, Sevigny LM, Kaneider NC, Lazarides K, Azabdaftari G, Sharifi S, Kuliopulos A
Mol. Cancer Ther., 2008;7(9):2746-57.
Species: Human
Sample Type: ovarian ascites

Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy.
Authors: Wendling D, Cedoz JP, Racadot E
Joint Bone Spine, 2008;75(5):559-62.
Species: Human
Sample Type: Serum

Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
Species: Human
Sample Type: Tissue Homogenates

Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?
Authors: McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert RE
Kidney Int., 2007;72(4):481-8.
Species: Human
Sample Type: Cell Culture Supernates

Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction.
Authors: Bodet C, Andrian E, Tanabe S, Grenier D
J. Cell. Physiol., 2007;212(1):189-94.
Species: Human
Sample Type: Cell Culture Supernates

Gingival fibroblasts inhibit MMP-1 and MMP-3 activities in an ex-vivo artery model.
Authors: Naveau A, Reinald N, Fournier B
Connect. Tissue Res., 2007;48(6):300-8.
Species: Human
Sample Type: Cell Culture Supernates

Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes.
Authors: Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK
FEBS Lett., 2007;581(9):1928-32.
Species: Human
Sample Type: Cell Culture Supernates

Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.
Authors: Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC
Invest. Ophthalmol. Vis. Sci., 2004;45(12):4302-11.
Species: Human
Sample Type: Cell Culture Supernates

Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease.
Authors: Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W
Arterioscler. Thromb. Vasc. Biol., 2003;23(2):283-8.
Species: Human
Sample Type: Serum

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

• Cancer Biomarkers
• Cell to Cell Adhesion Disassembly During EMT
• Collagen Modifying Enzymes
• EMT Induction
• Extracellular Matrix Remodeling and Cell Migration During EMT
• ICC / IHC Images: MMP-3
• Mesenchymal Cells and EMT
• Metalloproteases and Regulators
• MMP Modulation of Cytokines
• MMP-12 in Smoking-Related Pulmonary Disease
• MMPs, TIMPs and Related Molecules
• New Tools: Active MMP Activity Assays
• OSM Induction of Chondrocyte MMP and TIMP-3 Gene Expression