| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Improvement of biological and pharmacokinetic features of human interleukin-11 by site-directed mutagenesis.
Authors: Jung Y, Ahn H, Kim DS, Hwang YR, Ho SH, Kim JM, Kim S, Ma S, Kim S
Biochem. Biophys. Res. Commun., 2011;405(3):399-404.
Species: Human
Sample Type: Plasma
Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans.
Authors: Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A
J. Bone Miner. Res., 2011;26(8):1891-903.
Species: Human
Sample Type: Serum
Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia.
Authors: Yang L, Wang L, Zhao CH, Zhu XJ, Hou Y, Jun P, Hou M
Blood, 2010;116(20):4307-16.
Species: Human
Sample Type: Plasma
Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo.
Authors: Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM, Jones NL
Cancer Res., 2009;69(2):632-9.
Species: Human
Sample Type: Cell Culture Supernates
cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.
Authors: Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J
Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7281-6.
Species: Human
Sample Type: Cell Culture Supernates
Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans.
Authors: Liem-Moolenaar M, Cerneus D, Molloy C, End D, Brown K, de Kam M, Cohen A, van Hensbergen Y, Burggraaf J
2008;84(0):481.
Species: Human
Sample Type: Plasma
Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells.
Authors: Zdzisinska B, Bojarska-Junak A, Dmoszynska A, Kandefer-Szerszen M
Arch. Immunol. Ther. Exp. (Warsz.), 2008;56(3):207-21.
Species: Human
Sample Type: Cell Culture Supernates
Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation.
Authors: Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR
J. Neurosci., 2006;26(47):12174-85.
Species: Human
Sample Type: Cell Culture Supernates
Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005;31(5):335-48.
Species: Human
Sample Type: Cell Culture Supernates
Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis.
Authors: Chung HL, Kim WT, Kim JK, Choi EJ, Lee JH, Lee GH, Kim SG
Ann. Allergy Asthma Immunol., 2005;94(2):267-72.
Species: Human
Sample Type: Nasal Secretions
Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.
Authors: Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K
Heart Vessels, 2004;19(5):237-41.
Species: Human
Sample Type: Plasma
Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia.
Authors: Lopez-Karpovitch X, Barrales-Benitez O, Flores M, Piedras J
Cytokine, 2002;20(4):154-62.
Species: Human
Sample Type: Cell Culture Supernates
Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells.
Authors: Dimitriadis E, Robb L, Salamonsen LA
Mol. Hum. Reprod., 2002;8(7):636-43.
Species: Human
Sample Type: Cell Culture Supernates
Interleukin-11 induces Th2 polarization of human CD4(+) T cells.
Authors: Curti A, Ratta M, Corinti S, Girolomoni G, Ricci F, Tazzari P, Siena M, Grande A, Fogli M, Tura S, Lemoli RM
Blood, 2001;97(9):2758-63.
Species: Human
Sample Type: Cell Culture Supernates
Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response.
Authors: Carstanjen D, Regenfus M, Muller C, Salama A
Exp. Hematol., 2001;29(7):812-21.
Species: Human
Sample Type: Plasma
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| 背景 | Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling. |
