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货号： bs-19519R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19519R
- 英文名称
- NUDT3
- 中文名称
- NUDT3蛋白抗体
- 别 名
- Diphosphoinositol polyphosphate phosphohydrolase 1; Diphosphoinositol polyphosphate phosphohydrolase; DIPP 1; DIPP; DIPP-1; DIPP1; Nucleoside diphosphate linked moiety X motif 3; Nucleoside diphosphate-linked moiety X motif 3; Nudix (nucleoside diphosphate linked moiety X) type motif 3; Nudix motif 3; Nudix type motif 3; NUDT 3; Nudt3; NUDT3_HUMAN; P6-hexaphosphate hydrolase 1.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow,
- 产品应用
- IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 19kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NUDT3:1-100/172
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
Similarity:
Belongs to the Nudix hydrolase family. DIPP subfamily.
Contains 1 nudix hydrolase domain.
SWISS:
O95989
Gene ID:
11165
Database links:Entrez Gene: 11165Human
Entrez Gene: 618855Cow
Entrez Gene: 56409Mouse
Entrez Gene: 294292Rat
Omim: 609228Human
SwissProt: A2VE79Cow
SwissProt: O95989Human
SwissProt: Q9JI46Mouse
SwissProt: Q566C7Rat
Unigene: 188882Human
Unigene: 728786Human
Unigene: 144699Mouse
Unigene: 32556Mouse
Unigene: 473041Mouse
Unigene: 195252Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.