| 货号 | ES007 |
| 简介 | Substrate for ACE-2 and Caspase-1 |
| 来源 | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH. Mca: (7-Methoxycoumarin-4-yl)acetyl, Dnp: 2,4-Dinitrophenyl. |
| 产品组分 |
| 供应商 | R&D Systems |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. | |
| 生物活性 | Thepeptide substrate contains a highly fluorescent 7-methoxycoumarin group that isefficiently quenched by resonance energy transfer to the 2,4-dinitrophenylgroup. It can be used to measure the activities of peptidases that are capableof cleaving an amide bond between the fluorescent group and the quencher group,causing an increase in fluorescence. Itis an excellent substrate for caspase-1/interleukin-converting enzyme (ICE) andangiotensin I-converting enzyme-2 (ACE-2) (Enari, M. et al., 1996, Nature380:723; Vickers, C. et al., 2002, J. Biol. Chem. 277:14838). The cleavagesites by ICE and ACE-2 are the peptide bonds between Ala and Asp and betweenPro and Lys, respectively. |
| 运输条件 | Blue Ice |
| 预期分子量 | 1145.2 Da |
| 存放说明 | -20℃ |
| 纯度 | >95%, by HPLC. |
| 参考文献 |
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