| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis.
Authors: Allan E, Yates R
PLoS ONE, 2015;10(6):e0128945.
Species: Human
Sample Type: recombinant proteins
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Authors: Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung L, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu Z
Cell Res, 2014;24(3):344-58.
Species: Mouse
Sample Type: protein
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.
Authors: Zeeuwen PL, van Vlijmen-Willems IM, Cheng T
FASEB J., 2010;24(10):3744-55.
Species: Mouse
Sample Type: Tissue Homogenates
Application: Enzyme Substrate
Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5.
Authors: Cortesio CL, Jiang W
Arch. Biochem. Biophys., 2006;449(1):164-70.
Species: N/A
Sample Type: recombinant enzymes
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.
Authors: Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL
J. Biol. Chem., 2006;281(23):15893-9.
Species: Human
Sample Type: recombinant Legumain
Application: Enzyme Assay
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Authors: Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA
Genes Dev., 2006;20(5):543-56.
Species: Human
Sample Type: Buffer
Characterization of cathepsin L secreted by Sf21 insect cells.
Authors: Johnson GD, Jiang W
Arch. Biochem. Biophys., 2005;444(1):7-14.
Species: N/A
Sample Type: recombinant enzymes
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| 生物活性 | The peptide substrate contains a highly fluorescent7-methoxycoumarin group that is efficiently quenched by resonance energytransfer to the 2,4-dinitrophenyl group. It can be used to measure theactivities of peptidases that are capable of cleaving an amide bond between thefluorescent group and the quencher group, causing an increase in fluorescence. It is an excellent substrate for many cathespins. For example, it has been used to assay following recombinant human or mouse cathespins (rhCathespins or rmCathespins) followed by Catalog # in parentheses: rhCathepsin B (953-CY), rmCathepsin B (965-CY), rhCathepsin L (952-CY), and rhCathepsin V (1080-CY). |
