Neurofibromin 1 Blocking Peptide - (Dry Ice)
货号：
NB300-155PEP 基本售价：
1041.0 元 规格：
0.05 mg
产品信息
概述| 货号 | NB300-155PEP |
| 目标/特异性 | This peptide is specific for NB300-155 only. |
性能| 供应商 | Novus |
| 背景 | Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC). |
| 运输条件 | Dry Ice |
| 存放说明 | Store at -80C. Avoid freeze-thaw cycles. |
| 浓度 | 1.0 mg/ml |
