| 货号 | SMPK3 |
| 简介 | 50 ug each of rmEphrin-A1, rmEphrin-A2, rhEphrin-A3, rhEphrin-A4, rhEphrin-A5, rmEphrin-B1, rmEphrin-B2 and rhEphrin-B3 Fc Chimeras |
| 别名 | Ephrin |
| 供应商 | R&D Systems |
| 背景 | The Eph receptors represent the largest family of receptor tyrosine kinases (RTK) in the human genome. Their ligands, the ephrins, are also cell surface bound proteins, thereby requiring cell-cell interaction for binding and signaling. The ephrin ligands are divided into two categories: the A class are tethered to the membrane by a GPI anchor, and the B class are transmembrane proteins. Likewise, the receptors are also divided into two categories based on sequence similarity and ligand specificity. Ephrin-A ligands bind EphA receptors and ephrin-B ligands bind EphB receptors, with the exception of EphA4 which binds both A and B-type ligands. Eph/ephrin signaling is involved in vascular development, tissue-border formation, brain boundaries, cell migration, axon guidance, and synaptic plasticity. Eph/ephrin signaling activation generally results in repulsion of cells and often converges on the regulation of the cytoskeleton. Like most RTKs, ligand binding induces "forward" signaling, where a response occurs in the Eph receptor-containing cell. However, in some circumstances, this family can also exhibit "reverse signaling" where ephrins act as receptors responding to Eph signals, and ephrins signal back into their host cell. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
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