Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate (1 KT)
货号：
K-200B 基本售价：
7644.1 元 规格：
1 Kit
产品信息
概述| 货号 | K-200B |
| 别名 | ACTFS; HDM2; HDMX; MDM2 oncogene, E3 ubiquitin protein ligase |
全称 | Double Minute 2 Protein | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 4193 (Human); 17246 (Mouse) |
| 背景 | MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2. |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
| 参考文献 | - Cancer Biomarkers
- Checkpoint
- Chemokine Receptor Intracellular Signaling
- E3 Ubiquitin Ligases
- ICC / IHC Images: MDM2/HDM2
- Notch Pathway
- p53 Pathway
- Ubiquitin-related Molecules in the Akt Pathway
|
