E2Select Ubiquitin Conjugation Kit (1 KT)
货号：
K-982 基本售价：
5681.0 元 规格：
1 Kit
产品信息
概述| 货号 | K-982 |
| 别名 | RPS27A; UBA52; UBB ubiquitin B; UBB; UBC |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 7314 (Human); 298693 (Rat) |
| 背景 | Ubiquitin is a 76 amino acid (aa) protein that is ubiquitously expressed in all eukaryotic organisms. Ubiquitin is highly conserved with 96% aa sequence identity shared between human and yeast Ubiquitin, and 100% aa sequence identity shared between human and mouse Ubiquitin. In mammals, four Ubiquitin genes encode for two Ubiquitin-ribosomal fusion proteins and two poly-Ubiquitin proteins. Cleavage of the Ubiquitin precursors by deubiquitinating enzymes gives rise to identical Ubiquitin monomers each with a predicted molecular weight of 8.6 kDa. Conjugation of Ubiquitin to target proteins involves the formation of an isopeptide bond between the C-terminal glycine residue of Ubiquitin and a lysine residue in the target protein. This process of conjugation, referred to as ubiquitination or ubiquitylation, is a multi-step process that requires three enzymes: a Ubiquitin-activating (E1) enzyme, a Ubiquitin-conjugating (E2) enzyme, and a Ubiquitin ligase (E3). Ubiquitination is classically recognized as a mechanism to target proteins for degradation and as a result, Ubiquitin was originally named ATP-dependent Proteolysis Factor 1 (APF-1). In addition to protein degradation, ubiquitination has been shown to mediate a variety of biological processes such as signal transduction, endocytosis, and post-endocytic sorting. |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
| 参考文献 | - Cell Structure and Signaling Molecules
- Cell to Cell Adhesion Disassembly During EMT
- CXCR4: A Receptor for Extracellular Ubiquitin
- HIF Transcription Factors
- Negative Regulators of the Jak/STAT Pathway
- NFkB Pathway
- Notch Pathway
- Parkinsons Disease Related Molecules
- Ubiquitin
- Ubiquitin-related Molecules in the Akt Pathway
- Wnt Intracellular Signaling
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