概述| 货号 | K-800 |
| 别名 | FLJ43224; MGC104393; MGC125896; MGC125897; NEDD-8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; Rub1; Ubiquitin-like protein Nedd8 |
全称 | Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 4738 (Human); 18002 (Mouse); 25490 (Rat) |
| 应用文献 |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. A metal-based inhibitor of NEDD8-activating enzyme.
Authors: Zhong H, Yang H, Chan D, Leung C, Wang H, Ma D
PLoS ONE, 2012;7(11):e49574.
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| 背景 | NEDD8 (Neural precursor cell-expressed developmentally down-regulated gene 8; also known as Rub1) is a 6-8 kDa member of the ubiquitin family of proteins. It is expressed in striated muscle, and via its C-terminal Gly, forms covalent bonds with cullin family proteins. This conjugation generates ubiquitin ligase activity that regulates cell cycle proteins. Human pro-NEDD8 is 81 amino acids (aa) in length. It contains one ubiquitin-like domain (aa 1-65), and a 4-5 aa C-terminal propeptide that is cleaved to expose a C-terminal Gly residue that is used to generate a Gly-Lys intermolecular bond. Mature human NEDD8 shows 100% aa identity to NEDD8 from both mouse and canine. |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
| 参考文献 | - Developmental Factors Implicated in Neurodegeneration
- ICC / IHC Images: NEDD8
- Ubiquitin-like Modifiers (UBLs) and Regulators
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