| 货号 | 5477-KS-010 |
| 别名 | MAPK14; SAPK2a |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_139012 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1432 (Human); 26416 (Mouse); 81649 (Rat) |
| 生物活性 | The activity of p38 alpha is typically 148-201 nmol/min/mg using an ATF2 substrate (see activity assay protocol). |
| 背景 | p38 alpha (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and pro-inflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs) or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. |
| Accession # | NM_139012 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N-terminal GST tag |
| SDS-PAGE | 67 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
|
The approximate molecular weight is 67 kDa and the average purity is 90%. |
