| 货号 | 4595-KS-010 |
| 别名 | ASV; c-Src; EC 2.7.10; EC 2.7.10.2; pp60c-src; Rous sarcoma; RSVgp4; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 全称 | v-src Sarcoma [Schmidt-Ruppin A-2] Viral Oncogene Homolog |
| 反应种属 | Human |
| 来源 | E. coli-derived Accession # NM_005417 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6714 (Human); 20779 (Mouse); 83805 (Rat); 1491925 (Viral) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Sepsis-induced cardiac mitochondrial dysfunction involves altered mitochondrial-localization of tyrosine kinase Src and tyrosine phosphatase SHP2. | |
| 生物活性 | The activity of Src is typically 83-113 nmol/min/mg using a poly (Glu:Tyr, 4:1) synthetic peptide substrate (see Activity Assay Protocol). |
| 背景 | The Src family belongs to non-receptor tyrosine kinases. Src was originally identified as a transforming protein of the Rous Sarcoma Virus (RSV) that had the enzymatic ability to phosphorylate tyrosine in protein substrates (1). Src is over-expressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases (2). In addition to increasing cell proliferation, a key role of Src in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression. |
| Accession # | NM_005417 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N-terminal GST tag |
| SDS-PAGE | 83 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 83 kDa and the average purity is 95%. |
