| 货号 | 4590-KS-010 |
| 别名 | EC 2.7.11; EC 2.7.11.1; MGC131603; MGC43611; p160 ROCK-1; p160ROCK; p160-ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho kinase; rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; ROK beta | 全称 | Rho-associated, Coiled-Coil Containing Protein Kinase 1 |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived aa 17-535 Accession # NM_005406 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6093 (Human); 19877 (Mouse); 81762 (Rat) |
| 生物活性 | The activity of ROCK1 is typically 49-67 nmol/min/mg using a synthetic peptide substrate (see Activity Assay Protocol). |
| 背景 | ROCK1 is a ubiquitously expressed serine/threonine kinase that is a downstream target of the small GTPase RhoA. ROCK1 is involved in diverse cellular functions, including smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, and gene expression (1). ROCK1 contributes to the development of cardiac fibrosis and induction of fibrogenic cytokines in cardiomyocytes in response to pathological stimuli. ROCK1 knockout mice exhibit reduced perivascular and interstitial fibrosis, which is associated with reduced expression of a variety of extracellular matrix (ECM) proteins and fibrogenic cytokines (2). |
| Accession # | NM_005406 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N-terminal GST tag |
| SDS-PAGE | 85 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 85 kDa and the average purity is 90%. |
