| 货号 | 4589-KS-010 |
| 别名 | CADTK; CADTKCAK-beta; CAK beta; CAKB; Calcium-dependent tyrosine kinase; Cell adhesion kinase beta; EC 2.7.10; FADK2; FAK2; FAK2EC 2.7.10.2; Focal adhesion kinase 2; FRNK; PKB; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2B protein tyrosine kinase 2 beta; PTK2B; PYK2Related adhesion focal tyrosine kinase; RAFTK; RAFTKFADK 2 | 全称 | Proline-rich Tyrosine Kinase 2 |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_004103 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2185 (Human); 19229 (Mouse); 50646 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. CF airway smooth muscle transcriptome reveals a role for PYK2 | |
| 生物活性 | The activity of PYK2 is typically 216-292 nmol/min/mg using a poly (Glu:Tyr, 4:1) synthetic peptide substrate (see Activity Assay Protocol). |
| 背景 | PYK2 (also known as FAK2/RAFTK) is a member of the focal adhesion PTK family. PYK2/FAK2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration and by stress signals (1). Unlike FAK, which is widely expressed in various tissues and links transmembrane integrin receptors to intracellular pathways, PYK2/FAK2 is expressed mainly in the central nervous system and in cells derived from hematopoietic lineages. In osteoclasts, although FAK is expressed, PYK2/FAK2 appears to be the predominant mediator of integrin alpha V beta 3 signaling events that influence osteoclast physiology and pathology (2). |
| Accession # | NM_004103 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N-terminal His tag |
| SDS-PAGE | 39 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 39 kDa and the average purity is 90%. |
