| 货号 | 4467-KS-010 |
| 别名 | EC 2.7.10; FADK 1; FADK1; FADKFAK-related non-kinase polypeptide; FAK1FRNK; FAKEC 2.7.10.2; focal adhesion kinase 1; pp125FAK; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2; PTK2 | 全称 | Focal adhesion kinase 1 |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_153831 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5747 (Human); 14083 (Mouse); 25614 (Rat) |
| 生物活性 | The activity of FAK is typically 221-299 nmol/min/mg using a poly (Glu:Tyr, 4:1) synthetic peptide substrate (see Activity Assay Protocol). |
| 背景 | FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation (1). Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness (2). |
| Accession # | NM_153831 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N-terminal His tag |
| SDS-PAGE | 35 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 35 kDa and the average purity is 80%. |
