| 货号 | 4268-KS-010 |
| 别名 | cAMP-dependent protein kinase catalytic subunit alpha; Cs; EC 2.7.11; EC 2.7.11.11; MGC102831; MGC48865; PKA C-alpha; Pkaca; PKCA1; PKCD; PRKACA; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha | 全称 | cAMP-dependent Protein Kinase Catalytic Subunit alpha |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_002730 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5566 (Human); 18747 (Mouse); 25636 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch | |
| 生物活性 | The activity of PKA C alpha is typically 1626-2201 nmol/min/mg using a synthetic peptide substrate (see Activity Assay Protocol). |
| 背景 | The catalytic subunit C-alpha of PKA (PKA C alpha ) is a member of the Ser/Thr protein kinase family and has been assigned to chromosome region 19p13.1 (1). Null mutation in PKA C alpha leads to early postnatal lethality in the majority of C-alpha knockout mice. Surprisingly, a small percentage of C-alpha knockout mice, although runted, survived to adulthood. In these animals, compensatory increases in C-beta levels occurred in brain whereas many tissues, including skeletal muscle, heart, and sperm contained less than 10% of the normal PKA activity (2). |
| Accession # | NM_002730 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N-terminal GST tag |
| SDS-PAGE | 69 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 69 kDa and the average purity is 82%. |
