| 货号 | 1879-KS-010 |
| 别名 | EC 2.7.11; ERK-1; ERK1p44-MAPK; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK3; MGC20180; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; P44ERK1; p44-ERK1; p44mapk; PRKM3; PRKM3EC 2.7.11.24 | 全称 | Extracellular Signal-regulated Kinase 1 |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_002746 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5595 (Human); 26417 (Mouse); 50689 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Phosphatase-coupled universal kinase assay and kinetics for first-order-rate coupling reaction. | |
| 生物活性 | The activity of ERK1 is typically 329-445 nmol/min/mg using a myelin basic protein (MBP) substrate (see Activity Assay Protocol). |
| 背景 | ERK1 is a protein Serine/Threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines (1). Activation of ERK1 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK1 is ubiquitously distributed in tissues with the highest expression in heart, brain, and spinal cord. Activated ERK1 translocates into the nucleus where it phosphorylates various transcription factors. |
| Accession # | NM_002746 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Activated by active MEK1 in vitro |
| 预期分子量 | 44 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 44 kDa and the average purity is 90%. |
