Recombinant Mouse Active JNK1 Protein, CF (10 UG)
货号：
1776-KS-010 基本售价：
4858.1 元 规格：
10 ug
产品信息
概述| 货号 | 1776-KS-010 |
| 别名 | c-Jun N-terminal kinase 1; EC 2.7.11; EC 2.7.11.24; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1JNK1A2; JNK-46; JUN N-terminal kinase; MAP kinase 8; MAPK 8; MAPK8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8; PRKM8; PRKM8JNK; protein kinase JNK1; SAPK1; SAPK1JNK21B1/2; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1 |
全称 | C-Jun N-terminal Kinase 1 | | 反应种属 | Mouse |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_016700 |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 5599 (Human); 26420 (Mouse); 116554 (Rat) |
| 生物活性 | The activity of JNK1 is typically 92-124 nmol/min/mg using an ATF2 substrate (See Activity Assay Protocol). |
| 背景 | JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation on Threonine and Tyrosine residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on S63 and S73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity. |
| Accession # | NM_016700 |
| 运输条件 | Dry Ice |
N-terminal
Sequence Analysis | Using an N terminal GST tag |
| SDS-PAGE | 70 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 | - Derijard, B. et al. (1994) Cell 76:1025.
- Kolodziejczyk, S.M. et al. (2001) Curr. Biol. 11:1278.
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参考图片The approximate molecular weight is 70 kDa and the average purity is 83%. |
