| 货号 | 1775-KS-010 |
| 别名 | AKT; EC 2.7.11; EC 2.7.11.1; PKB alpha; PKBMGC99656; PRKBA; Protein kinase B; Proto-oncogene c-Akt; rac protein kinase alpha; RAC-alpha serine/threonine-protein kinase; RAC-alpha; RAC-PK-alpha; RACPKB-ALPHA; v-akt murine thymoma viral oncogene homolog 1 | 全称 | v-Akt Murine Thymoma Viral Oncogene Homolog 1 |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_005163 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 207 (Human); 11651 (Mouse); 25233 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. | |
| 生物活性 | The activity of Akt1 is typically 103-139 nmol/min/mg using a synthetic peptide substrate (RPRAATF) (see Activity Assay Protocol). |
| 背景 | Akt1, also known as PKB alpha, is a serine/threonine kinase that belongs to the Akt family. Akt1 is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). Akt1 is frequently over-expressed and active in many types of human cancers including cancers of colon, breast, brain, pancreas, and prostate as well as lymphomas and leukemias (2). |
| Accession # | NM_005163 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N terminal GST tag |
| SDS-PAGE | 85 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 85 kDa and the average purity is 90%. |
