概述| 货号 | K-260 |
| 别名 | API1Hiap-2; apoptosis inhibitor 1; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 2; BIRC2; cIAP1; c-IAP1; hIAP2; HIAP-2; IAP homolog B; IAP2; IAP-2; Inhibitor of apoptosis protein 2; MIHB; MIHBHIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RNF48hiap-2; TNFR2-TRAF-signaling complex protein 2 |
全称 | Cellular Inhibitor of Apoptosis Protein 1 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 329 (Human); 11797 (Mouse) |
| 背景 | Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi. |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
| 参考文献 | - Caspases and Regulators
- Cysteine Proteases and Regulators
- E3 Ubiquitin Ligases
- ICC / IHC Images: cIAP-1/HIAP-2
- Inhibitors of Apoptosis (IAPs) and Regulators
- Interactive Pathway: Apoptosis Signaling Pathways
- Mini-review: Apoptosis I
- New Tools: Proteases & Inhibitors
- TNF Superfamily Regulators
- Ubiquitin-related Molecules in the Akt Pathway
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