| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573.
Authors: Neukamm, Sabine S, Toth, Rachel, Morrice, Nick, Campbell, David G, Mackintosh, Carol, Lehmann, Rainer, Haering, Hans-Ulr, Schleicher, Erwin D, Weigert, Cora
PLoS ONE, 2012;7(8):e43296.
Species: Human
Sample Type: Cell Lysates
Application: WB |
| 背景 | 14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric proteins present in high abundance in all eukaryotic cells. 14-3-3 proteins act as key regulators of intracellular signal transduction through their ability to bind specific motifs containing phosphorylated serine or threonine residues. There are at least seven distinct 14-3-3 genes in vertebrates: alpha/beta, epsilon, eta, gamma, theta, sigma, and zeta/delta. |
