Rat CCR6 Alexa Fluor 405 Antibody (Clone 876515) (100 UG)
货号：
FAB8320V-100UG 基本售价：
4659.8 元 规格：
100 UG
产品信息
概述| 货号 | FAB8320V-100UG |
| 别名 | BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects rat CCR6 in direct ELISAs. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 1235 (Human); 12458 (Mouse); 308163 (Rat) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | NSO mouse myeloma cell line transfected with rat CCR6
Met1-Met366
Accession # Q5BK58 |
| 生物活性 | Rat |
| 标记 | Alexa Fluor 405 |
| 背景 | CCR6 is an approximately 45 kDa G-protein linked seven transmembrane domain receptor that binds the chemokine CCL20/MIP-3 alpha. Among hematopoietic cells, CCR6 is expressed on B cells, immature dendritic cells, neutrophils, and various T cell subsets (e.g. CD4+ T cells, regulatory T cells, effector memory Th17 cells, and g/d T cells). It is upregulated in several cancers, Alzheimer’s brain, and the airways in obstructive pulmonary disease. CCR6 plays an important role in mucosal immunity, IgE mediated allergic reactions, immune cell infiltration into sites of inflammation, and tumor cell invasiveness. It also promotes chemotaxis and tumor angiogenesis in response to beta defensins. Rat CCR6 shares 74% and 87% amino acid sequence identity with human and mouse CCR6, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - B Cell Chemotaxis, Migration, and Adhesion
- CC Chemokines and Receptors
- Chemokine Receptors
- Chemokines and Receptors in Allergy and Asthma
- Chemokines and Receptors in Angiogenesis
- Dendritic Cell Adhesion and Migration
- gamma delta T Cells
- LTi Cells
- Monocyte Markers
- Natural Killer T (NKT) Cells
- Regulatory T Cells (Tregs)
- T Cell Migration/Adhesion
- Th17 Cells
- Th22 Cells
|
参考图片Detection of CCR6 in HEK293 Human Cell Line Transfected with Rat CCR6 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) rat CCR6 or (B) irrelevant transfectant and eGFP was stained with Mouse Anti-Rat CCR6 Alexa Fluor® 405‑conjugated Monoclonal Antibody (Catalog # FAB8320V). Quadrant markers were set based on control antibody staining (Catalog # IC0041V). View our protocol for Staining Membrane-associated Proteins. |
