Rat IL-7 R alpha/CD127 Phycoerythrin Affinity Purified PAb (100 TESTS)【科瑞奥博】

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Rat IL-7 R alpha/CD127 Phycoerythrin Affinity Purified PAb (100 TESTS)

货号： FAB5607P 基本售价： 4659.8 元规格： 100 Tests

产品信息

概述
货号	FAB5607P
别名	CD127 antigen; CD127; CD127ILRA; CDW127; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL7R; IL7RA; IL-7RA; IL-7R-alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; interleukin 7 receptor; interleukin-7 receptor subunit alpha
全称	Interleukin 7 Receptor alpha
反应种属	Rat
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects rat IL-7 R alpha /CD127 in direct ELISAs and Western blots. In direct ELISAs, approximately 60% cross-reactivity with recombinant mouse IL-7 R alpha and less than 10% cross-reactivity with recombinant human IL-7 R alpha is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3575 (Human); 16197 (Mouse); 294797 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B(+) subset Authors: A Sudworth, JT Vaage, M Inngjerdin, L Kveberg J. Leukoc. Biol., 2017;0(0):. Species: Rat Sample Type: Whole Cells Application: Flow
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant rat IL-7 R alpha /CD127 Glu21-Asp239 Accession # NP_001099888
生物活性	Rat
标记	Phycoerythrin
背景	IL-7 R alpha (IL-7 Receptor alpha; also known as CD127) is a 60-70 kDa member of the type I cytokine receptor family of molecules. It is expressed on resting naïve and memory CD8⁺ T cells, DN thymocytes, pre-B cells, Th1 CD4⁺ T cells, dendritic cells and monocytes. IL-7 R alpha heterodimerizes with both the gamma c chain to create the IL-7 receptor, and the TSLPR subunit to generate the TSLP receptor. IL-7 R alpha participates in T cell differentiation, naïve T cell survival, and CD4⁺ thymocyte proliferation. Mature rat IL-7 R alpha is a 437 amino acid (aa) type I transmembrane glycoprotein. It contains a 219 aa extracellular region (aa 21-239) that possesses one type III fibronectin domain (aa 129-222), and a 193 aa cytoplasmic tail that shows a key phosphorylation site at Tyr447. Over aa 21-239, rat IL-7 R alpha shares 79% and 67% aa identity with mouse and human IL-7 R alpha, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Development and Differentiation B Cell Markers Common gamma Chain Receptor Family Group 1 ILCs Group 2 ILCs Hematopoietic Progenitor Cell Markers Human CD Marker Products Interactive Pathway: IL-7 Signaling Pathways Isolation, Culture, and Identification of Natural Killer Cells LTi Cells Lymphoid Lineage Markers Natural Killer T (NKT) Cells NCR+ILC3 NCR-ILC3 Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Cytokine Signaling

参考图片

Detection of IL‑7 R alpha /CD127 in Rat Splenocytes by Flow Cytometry. Rat splenocytes were stained with anti-rat CD4 APC‑conjugated antibody and either (A) Sheep Anti-Rat IL‑7 R alpha /CD127 PE‑conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB5607P) or (B) Normal Sheep IgG Phycoerythrin Control (Catalog # IC016P). View our protocol for Staining Membrane-associated Proteins.