Metablastin/Strathmin Pure 53 50ug
货号：
611146 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611146 |
| 描述 | The regulation of microtubule (MT) assembly is vital to cellular processes such as organelle transport, organization of the cytoplasm, and intracellular movement of cell surface receptors. MTs are composed of tubulin subunits that exist in dynamic equilibrium between free tubulin dimers and MTs. The instability of MTs is determined by the rates of growth and shrinkage of tubulin polymers and by frequencies of transitions from growth to shrinkage (catastrophes) or from shrinkage to growth (rescues). The most well known MT regulators are the microtubule associated proteins (MAPs) which directly bind and stabilize MTs. Metablastin (stathmin) opposes MAP activity by inducing catastrophes.Metablastin is variably phosphorylated on multiple Ser residues by kinases that are regulated by the cell cycle or by external signals. Phosphorylation of metablastin inhibits its ability to destabilize MTs and, in turn, induces tubulin polymerization. Metablastin activity is turned off during the cell cycle to allow spindle formation and cell division. Thus, metablastin is thought to function to regulate the dynamics of MT formation in response to external signals during the interphase of the cell cycle. |
| 别名 | Stathmin, Metablastin |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF, Bioimg |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Metablastin aa. 38-147 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
