IL-27/IL-35 EBI3 Subunit Antibody Pack
货号：
NBP2-29379 基本售价：
10707.6 元 规格：
-
产品信息
概述| 货号 | NBP2-29379 |
| 应用 | WB, Flow-IC, IHC-P |
性能| 供应商 | Novus |
| 背景 | EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function. EBI3 dimerizes with p28 and p35 subunits of IL-12 to form new proteins IL-27 and IL-35, respectively (Honglian Tong et al, 2010). IL-27 is an early product of activated antigen presenting cell that is produced upon TLR ligation. It negatively regulates Th17 cell differentiation. EBI3 is widely expressed and its expression in dendritic cell is transcriptionally regulated by TLR signaling via MyD88 and NF-kappaB during innate immune responses preceding cytokine driven Th cell development. EBI3 signal inhibits delayed-type hypersensitivity responses by suppressing IL-17 production and inducing IL-10 hyperproduction. EBI3 may play a novel role in controlling tumor metastasis via lung CD8+ T cells, and its deficiency is associated with a diminished production of Th2 cytokines which are known to regulate allergic airway inflammation in asthma. Targeted deletion of EBI3 protects mice from lung metastasis (Kerstin A et al, 2008). Following are the different antibodies included in this EBI3 Sampler Kit: |
| 存放说明 | Store at -20C. Avoid freeze-thaw cycles. |
| 纯度 | Immunogen affinity purified |
参考图片Western Blot: EBI3 Antibody Pack [NBP2-29379] - Testing of mouse EBI3 monoclonal antibody at A) 0.1 ug/ml on recombinant protein and B) 3 ug/ml on recombinant mouse IL-35 protein. Goat anti-rat Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. |
